Neurofibromin 1 Antibody (McNFn27b) [DyLight 405]


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Product Details

Reactivity Hu, Mu, Rt, GPSpecies Glossary
Applications ELISA, IHC, IHC-P
DyLight 405

Neurofibromin 1 Antibody (McNFn27b) [DyLight 405] Summary

A highly conserved N-terminal peptide, corresponding to amino acids 27-41 of human Neurofibromin 1. [UniProt# P21359]
IgG1 Kappa
Immunogen affinity purified
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  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
Application Notes
This Neurofibromin 1 (McNFn27b) antibody can be used for ELISA, Immunohistochemistry on paraffin-embedded sections and Immunoprecipitation. Antigen retrieval is not required for immunostaining of frozen sections. Antigen retrieval with trypsin or citrate improves IHC on paraffin sections.

Packaging, Storage & Formulations

Store at 4C in the dark.
50mM Sodium Borate
0.05% Sodium Azide
Immunogen affinity purified


Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Neurofibromin 1 Antibody (McNFn27b) [DyLight 405]

  • DKFZp686J1293
  • FLJ21220
  • Neurofibromatosis-related protein NF-1
  • neurofibromin 1
  • neurofibromin
  • NFNS
  • VRNF
  • WSS


Neurofibromin 1 (NF1), the Nf1 gene product, is a large protein which contains a central Ras-GTPase-activating (RasGAP) domain and is suggested to function as a negative regulator of proto-oncogene RAS and downstream effectors. It stimulates the GTPase activity of RAS and acts as regulator of RAS signaling. Consistent with its biochemical activity, NF1 functions as a tumor-suppressor gene in juvenile myelomonocytic leukemia (JMML), and diseased BM cells exhibit aberrant Raf/MEK/ERK signaling. Moreover, NF1 shows greater affinity for Ras GAP, but lower specific activity. Besides JMML, defects in NF1 have also been linked to neurofibromatosis type 1 (NF1), Watson syndrome (WS), familial spinal neurofibromatosis (FSNF), neurofibromatosis-Noonan syndrome (NFNS), colorectal cancer (CRC).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies


Isotype Controls

Other Available Formats

Biotin Labeled NB300-154B
DyLight 488 Labeled NB300-154G
DyLight 550 Labeled NB300-154R
DyLight 650 Labeled NB300-154C
FITC Labeled NB300-154F
HRP Labeled NB300-154H

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Bioinformatics Tool for Neurofibromin 1 Antibody (NB300-154V)

Discover related pathways, diseases and genes to Neurofibromin 1 Antibody (NB300-154V). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on Neurofibromin 1.

Developmental regulator Daam2 promotes glial cell tumors by degrading Von Hippel-Lindau protein
By Jamshed Arslan Pharm.D. Glioblastoma is an aggressive type of cancer that forms from the star-shaped glial cells of the central nervous system, called astrocytes. Intriguingly, several genes linked to glioblasto...  Read full blog post.

Neurofibromatosis Infographic
Neurofibromatosis (NF) is a genetic disorder caused by mutations in the NF1, NF2 or SMARCB1 genes which lead to tumor growth on nerves throughout the body. Although the tumors are usually benign, they still require chemotherapy to shrink and may becom...  Read full blog post.

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Gene Symbol NF1