Neudesin Antibody (737130) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: WB, IHC
• Clone: 737130
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

Neudesin Antibody (737130) [Alexa Fluor® 700] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human Neudesin
  Gly32-Phe172
  Accession # Q9UMX5
• Specificity: Detects human Neudesin in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Neudesin Antibody (737130) [Alexa Fluor® 700]

• Cell immortalization-related protein 2
• CIR2
• CIR2cell growth-inhibiting protein 47
• NENF
• Neudesin
• neuron derived neurotrophic factor
• Neuron-derived neurotrophic factor
• SCIRP10
• SCIRP10-related protein
• Secreted protein of unknown function
• Spinal cord injury related protein 10
• SPUF protein
• SPUF
• SPUFneudesin

Background

Neudesin (Neuron-derived neurotrophic secreted protein; also CIR2 and SPUF) is a secreted, 20-21 kDa member of the MAPR (membrane-associated progesterone receptor) subfamily, cytochrome b5 family of molecules. It is expressed by CNS neuronal progenitors and neurons, plus preadipocytes in white adipose tissue. Regarding activity, it promotes neuronal differentiation with limited proliferation and serves as a neuron survival factor. By contrast, it inhibits both astrocyte and adipocyte differentiation. Mature human Neudesin is 141 amino acids (aa) in length (aa 32-172). It contains one cytochrome b5-like heme-binding domain (aa 44-129) and an acetylated lysine residue at Lys136. The heme-binding domain does bind heme, and this accounts for 5-6 kDa of its circulating molecular weight. The presence of a heme moiety is necessary for activity. Mature human Neudesin shares 97% aa identity with mature mouse Neudesin

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.