Nav1.5 Products

Description

Nav1.5 is encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in two transcript variants encoding separate isoforms which differ by a single amino acid. Mutation nomenclature has been assigned with respect to the longer isoform. This antibody is expected to recognise both reported isoforms (NP_000326 and NP_932173).

Bioinformatics

Uniprot	AAH51374.1 Human NP_932173.1 Human
Product By Gene ID	6331
Alternate Names	cardiac sodium channel alpha subunit cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit CDCD2VF1 HB1sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) HB2 HBBD HH1CMD1E ICCD IVF LQT3SSS1CMPD2 Nav1.5 PFHB1 Sodium channel protein cardiac muscle subunit alpha sodium channel protein type 5 subunit alpha sodium channel protein type V alpha subunit Sodium channel protein type V subunit alpha sodium channel, voltage-gated, type V, alpha subunit Voltage-gated sodium channel subunit alpha Nav1.5