Myosin VIIa Antibody (24GB665)

• Reactivity: Hu, Mu, Rt
• Applications: WB, Flow, ICC/IF
• Clone: 24GB665
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

Myosin VIIa Antibody (24GB665) Summary

• Immunogen: A synthesized peptide derived from human Myosin VIIa (Uniprot: Q13402)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: MYO7A
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 50% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Myosin VIIa Antibody (24GB665)

• deafness, autosomal dominant 11
• deafness, autosomal recessive 2
• DFNA11
• DFNB2
• myosin VIIA
• myosin-VIIa
• MYOVIIA
• MYU7A
• USH1Bsevere))

Background

Myosin VIIa is a member of the myosin superfamily of actin-based motor proteins. Defects in the myosin VIIa gene are responsible for hearing impairment in shaker-1 (sh1) mice and causes Usher syndrome IB in humans. Usher syndrome associates congenital deafness, vestibular dysfunction, and retinitis pigmentosa and is the most common form of combined deafness and blindness. Structural features of myosin VIIa protein include an ATP binding N-terminal motor domain, a central region which possess five light-chain binding (IQ) motifs, and a C-terminal domain with three myosin tail homology (MyTH4) and talin-like homology regions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MYO7A