MSH2 Antibody (25D12)

Immunohistochemistry-Paraffin: MSH2 Antibody (25D12) [NBP2-26489] - Formalin fixed paraffin embedded human tonsil stained with MSH2 antibody (NBP2-26489).

Product Discontinued

MSH2 Antibody (25D12) Summary

• Immunogen: BALB/C mice were injected with recombinant human MSH2 protein.
• Localization: Nuclear
• Specificity: This antibody reacts with a 102 kDa protein known as MSH2 (mismatch repair protein 2).
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: MSH2
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:10 - 1:2000
  • Immunohistochemistry-Paraffin 1:10-1:25

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: Tissue culture supernatant
• Preservative: 0.05% Sodium Azide
• Purity: Tissue culture supernatant

Alternate Names for MSH2 Antibody (25D12)

• COCA1
• DNA mismatch repair protein Msh2
• FCC1
• hMSH2
• HNPCC
• HNPCC1
• HNPCC1mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1)
• LCFS2
• MSH2
• mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
• MutS protein homolog 2

Background

MSH2 protein is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MSH2