Mouse Osteoactivin/GPNMB DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Osteoactivin/GPNMB DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Gpnmb

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Osteoactivin/GPNMB DuoSet ELISA, 15 Plate

• DC-HIL
• glycoprotein (transmembrane) nmb
• glycoprotein NMB
• GPNMB
• HGFIN
• HGFINglycoprotein nmb-like protein
• NMBosteoactivin
• Osteoactivin
• Transmembrane glycoprotein HGFIN
• transmembrane glycoprotein NMB

Background

Osteoactivin, also known as transmembrane glycoprotein NMB (GPNMB) and dendritic cell-associated transmembrane protein (DC-HIL), is a type I transmembrane glycoprotein that is found either on the plasma membrane or on membranes of the endosome/lysosome compartment. The extracellular region of Osteoactivin contains a heparin-binding motif and an integrin recognition RGD domain, while the cytocylasmic region contains an immunoreceptor tyrosine-based activation motif (ITAM) and lysosomal targeting motif.

Publications for Osteoactivin/GPNMB (DY2330)(11)

Publications using DY2330

• Wallings, RL;Gillett, DA;Staley, HA;Mahn, S;Mark, J;Neighbarger, N;Kordasiewicz, H;Hirst, WD;Tansey, MG; ASO-mediated knockdown of GPNMB in mutant- GRN and Grn -deficient peripheral myeloid cells disrupts lysosomal function and immune responses bioRxiv : the preprint server for biology 2024-07-23 [PMID: 39211224] (Mouse)
• M Fukaura, Y Ishitsuka, S Shirakawa, N Ushihama, Y Yamada, Y Kondo, T Takeo, N Nakagata, K Motoyama, T Higashi, H Arima, Y Kurauchi, T Seki, H Katsuki, K Higaki, M Matsuo, T Irie Intracerebroventricular Treatment with 2-Hydroxypropyl-&beta-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice International Journal of Molecular Sciences, 2021-01-05;22(1):. 2021-01-05 [PMID: 33466390] (Mouse)
• M Hüttenrauc, I Ogorek, H Klafki, M Otto, C Stadelmann, S Weggen, J Wiltfang, O Wirths Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia Acta Neuropathol Commun, 2018-10-19;6(1):108. 2018-10-19 [PMID: 30340518] (Mouse)
• MJ Tol, MJC van der Li, TL Gabriel, JJ Hagen, S Scheij, T Veenendaal, J Klumperman, WE Donker-Koo, AJ Verhoeven, H Overkleeft, JM Aerts, CA Argmann, M van Eijk HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution Autophagy, 2018-02-17;0(0):1-13. 2018-02-17 [PMID: 29455584] (Mouse)
• Vagishwari Murugesan Validating glycoprotein non-metastatic melanoma B (gpNMB, osteoactivin), a new biomarker of Gaucher disease Blood Cells Mol. Dis, 2016-12-13;0(0):. 2016-12-13 [PMID: 28003098] (Mouse)
• Elevation of glycoprotein nonmetastatic melanoma protein B in type 1 Gaucher disease patients and mouse models FEBS Open Bio, 2016-07-30;6(9):902-13. 2016-07-30 [PMID: 27642553] (Mouse)
• S Bhattachar, L Feferman, JK Tobacman Inhibition of Phosphatase Activity Follows Decline in Sulfatase Activity and Leads to Transcriptional Effects through Sustained Phosphorylation of Transcription Factor MITF PLoS ONE, 2016-04-14;11(4):e0153463. 2016-04-14 [PMID: 27078017] (Mouse)
• Marques A, Gabriel T, Aten J, van Roomen C, Ottenhoff R, Claessen N, Alfonso P, Irun P, Giraldo P, Aerts J, van Eijk M Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease. PLoS ONE, 2016-01-15;11(1):e0147208. 2016-01-15 [PMID: 26771826] (Mouse)
• Zigdon , Hila, Savidor , Alon, Levin , Yishai, Meshcheriakova , Anna, Schiffmann , Raphael, Futerman , Anthony Identification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease. PLoS ONE, 2015-03-16;10(3):e0120194. 2015-03-16 [PMID: 25775479] (Mouse)
• Gabriel T, Tol M, Ottenhof R, van Roomen C, Aten J, Claessen N, Hooibrink B, de Weijer B, Serlie M, Argmann C, van Elsenburg L, Aerts J, van Eijk M Lysosomal stress in obese adipose tissue macrophages contributes to MITF-dependent Gpnmb induction. Diabetes, 2014-05-01;63(10):3310-23. 2014-05-01 [PMID: 24789918] (Mouse)
• Abdelmagid S, Belcher J, Moussa F, Lababidi S, Sondag G, Novak K, Sanyurah A, Frara N, Razmpour R, Del Carpio-Cano F, Safadi F Mutation in osteoactivin decreases bone formation in vivo and osteoblast differentiation in vitro. Am J Pathol, 2014-01-23;184(3):697-713. 2014-01-23 [PMID: 24462663] (Mouse)

Bioinformatics

• Gene Symbol: Gpnmb