MKP-3/DUSP6 Antibody

Images

 
Western Blot: MKP-3/DUSP6 Antibody [H00001848-D01P] - Analysis of DUSP6 expression in human pancreas.
Western Blot: MKP-3/DUSP6 Antibody [H00001848-D01P] - Analysis of DUSP6 expression in transfected 293T cell line by DUSP6 polyclonal antibody.Lane 1: DUSP6 transfected lysate(42.30 KDa).Lane 2: Non-transfected lysate.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

MKP-3/DUSP6 Antibody Summary

Immunogen
DUSP6 (NP_001937.2, 1 a.a. - 381 a.a.) full-length human protein. MIDTLRPVPFASEMAISKTVAWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRGEDRDRFTRRCGTDTVVLYDESSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFSLHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTTPSNQNVYQVDSLQST
Specificity
Reacts with dual specificity phosphatase 6.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DUSP6
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
This antibody is reactive against tissue and transfected lysate in WB and as a detection antibody in ELISA.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4)
Preservative
No Preservative
Purity
Protein A purified

Notes

Quality control test: Antibody reactive against mammalian transfected lysate.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MKP-3/DUSP6 Antibody

  • dual specificity phosphatase 6
  • Dual specificity protein phosphatase PYST1
  • DUSP6
  • EC 3.1.3.16
  • EC 3.1.3.48
  • MAP kinase phosphatase 3
  • Mitogen-activated protein kinase phosphatase 3
  • MKP3
  • MKP-3
  • MKP3serine/threonine specific protein phosphatase
  • PYST1
  • PYST1dual specificity protein phosphatase 6

Background

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol DUSP6
Entrez
Uniprot