MKP-1/DUSP1 Antibody (408612) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: IHC
• Clone: 408612
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 594

MKP-1/DUSP1 Antibody (408612) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human MKP-1
  Met1-Cys367
  Accession # P28562
• Specificity: Detects human MKP-1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) MKP-2, rhMKP-3, or rhMKP-5 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MKP-1/DUSP1 Antibody (408612) [Alexa Fluor® 594]

• CL100
• CL100MAP kinase phosphatase 1
• dual specificity phosphatase 1
• Dual specificity protein phosphatase hVH1
• DUSP1
• EC 3.1.3.16
• EC 3.1.3.48
• HVH1
• Mitogen-activated protein kinase phosphatase 1
• MKP1
• MKP-1
• MKP-1dual specificity protein phosphatase 1
• Protein-tyrosine phosphatase CL100
• PTPN10
• PTPN10serine/threonine specific protein phosphatase
• VH1

Background

MKP-1, also known as PTPN10, DUSP1, and CL100, is an approximately 45 kDa Ser/Thr protein phosphatase that dephosphorylates p38 MAPK and JNK. Acetylation of MKP-1 enhances this activity and limits the inflammation-induced signaling downstream of TLR proteins. Within aa 1-367, human MKP-1 shares 97% aa sequence identity with mouse and rat MKP-1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.