MKP-1/DUSP1 Products

Antibodies
MKP-1/DUSP1 Antibody
MKP-1/DUSP1 Antibody
NB100-834
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
MKP-1/DUSP1 Antibody (408612) ...
MKP-1/DUSP1 Antibody (408612)
MAB7168
Species: Hu
Applications: IHC
Host: Rat Monoclonal
MKP-1/DUSP1 Antibody
MKP-1/DUSP1 Antibody
NBP1-61719
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
MKP-1/DUSP1 Recombinant Prote ...
MKP-1/DUSP1 Recombinant Protein
H00001843-P01
Species: Hu
Applications: WB, ELISA, PA
MKP-1/DUSP1 Partial Recombina ...
MKP-1/DUSP1 Partial Recombinant Pr...
H00001843-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
MKP-1/DUSP1 RNAi
MKP-1/DUSP1 RNAi
H00001843-R01
Species: Hu

Description

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Product By Gene ID 1843
Alternate Names
  • Protein-tyrosine phosphatase CL100
  • VH1
  • Mitogen-activated protein kinase phosphatase 1
  • EC 3.1.3.48
  • Dual specificity protein phosphatase hVH1
  • EC 3.1.3.16
  • HVH1
  • PTPN10serine/threonine specific protein phosphatase
  • MKP-1dual specificity protein phosphatase 1
  • CL100MAP kinase phosphatase 1
  • MKP1
  • dual specificity phosphatase 1

Research Areas for MKP-1/DUSP1

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Protein Phosphatase

Bioinformatics Tool for MKP-1/DUSP1

Discover related pathways, diseases and genes to MKP-1/DUSP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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