Maxi Potassium channel beta Antibody Blocking Peptide

Product Discontinued

Maxi Potassium channel beta Antibody Blocking Peptide Summary

• Description: A KCNMB1 antibody blocking peptide.

  Source: Synthetic

  Amino Acid Sequence: YHTEDTRDQNQQC

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: KCNMB1
• Purity: >95%, by HPLC.
• Endotoxin Note: N/A

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NB 300-535. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~70-fold) for competitive inhibition of antibody-protein binding reactions. For further blocking peptide related protocol, click here.
• Theoretical MW: 1.75 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized in PBS with 1 mg/mL BSA
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: >95%, by HPLC.
• Reconstitution Instructions: Reconstitute with 0.1 ml of distilled water.

Alternate Names for Maxi Potassium channel beta Antibody Blocking Peptide

• BK channel beta subunit
• BK channel subunit beta-1
• BKbeta
• BKbeta1
• Calcium-activated potassium channel subunit beta
• calcium-activated potassium channel subunit beta-1
• Calcium-activated potassium channel, subfamily M subunit beta-1
• Charybdotoxin receptor subunit beta-1
• Hbeta1
• hslo-beta
• K(VCA)beta
• K(VCA)beta-1
• KCNMB1
• large conductance Ca2+-activated K+ channel beta 1 subunit
• Maxi K channel beta subunit
• Maxi K channel subunit beta-1
• Maxi Potassium channel beta
• potassium large conductance calcium-activated channel, subfamily M, beta member1
• Slo-beta
• Slo-beta-1

Background

Potassium channels are a group of ubiquitously expressed proteins that serve numerous functions in excitable and non-excitable cells. One class of integral membrane potassium channels is the large conductance, calcium-activated potassium channel (Maxi K+). Maxi K+ differs from most other potassium channels in that its activation is controlled by both increases in intracellular calcium and by membrane depolarization. Maxi K+ dual activation is possible because of its structure. The core of the channel, which is similar to other potassium channels, is a Maxi K+ alpha homotetramer that contains both a voltage sensor and an intracellular calcium binding domain. In vascular smooth muscle, an auxiliary beta-subunit is found in a 1:1 stoichiometry. The beta-subunit exhibits its effect on the Maxi K+ channel by effectively decreasing by 5- to 10- fold the concentration of calcium required to keep the pore open. Maxi K+ beta is the target for possible therapeutics because of its role in blood flow and blood pressure regulation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: KCNMB1