Matriptase/ST14 Antibody - Humanized - Low Endotoxin, Azide and BSA Free

• Reactivity: Hu
• Applications: ELISA, Flow, Func
• Clonality: Monoclonal
• Host: Human
• Conjugate: Unconjugated
• Format: Low Endotoxin, Azide and BSA Free
• Concentration: LYOPH

Matriptase/ST14 Antibody - Humanized - Low Endotoxin, Azide and BSA Free Summary

• Description: The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 145.5 kDa.
  
  This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
  
  Patent #: US20160289338
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Matriptase
• Source: CHO
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Gene: ST14
• Purity: Protein A purified
• Endotoxin Note: < 0.001EU/ug,determined by LAL method.

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Functional

Packaging, Storage & Formulations

• Storage: Store at -20C in powder form. Store at -80C once reconstituted.
• Buffer: Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein A purified
• Reconstitution Instructions: Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for Matriptase/ST14 Antibody - Humanized - Low Endotoxin, Azide and BSA Free

• EC 3.4.21
• Epithin
• HAI
• Matriptase
• Membrane-type serine protease 1
• MTSP1
• MT-SP1EC 3.4.21.109
• prostamin
• PRSS14
• Serine protease 14
• Serine protease TADG-15
• SNC19
• SNC19MTSP1
• ST14
• suppression of tumorigenicity 14 (colon carcinoma)
• suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
• suppressor of tumorigenicity 14 protein
• TADG15
• TADG-15
• TMPRSS14
• tumor associated differentially expressed gene 15 protein
• Tumor-associated differentially-expressed gene 15 protein

Background

ST14 is encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ST14
• Uniprot:
  • Q9Y5Y6()