Marapsin/Pancreasin Antibody [Alexa Fluor™ Plus 488]

• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 488

Marapsin/Pancreasin Antibody [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects mouse Marapsin/Pancreasin in direct ELISAs and Western blots. In direct ELISAs, approximately 15% cross-reactivity with recombinant human Marapsin is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Marapsin/Pancreasin Antibody [Alexa Fluor™ Plus 488]

• CAP-2
• CAPH2
• channel-activating protease 2
• EC 3.4.21
• EC 3.4.21.-
• EC 3.4.21.4
• EC 3.4.21.43
• Marapsin
• MPN
• MPNMarapsin
• Pancreasin
• protease, serine 27
• PRSS27
• serine protease 27

Background

Marapsin, Pancreasin, and channel-activating protease 2 (CAP-2), encoded by the Prss27 gene, are different names given for the same serine protease that is expressed strongly in the pancreas (1). The mouse protein is synthesized with a signal peptide (amino acid residues 1‑22), a pro peptide (residues 23‑37) and a mature chain (residues 38‑290) corresponding to the serine protease domain. The full-length protein was expressed and the secreted protein purified. The N-terminal sequencing results indicate that the purified protein is a disulfide bond-linked dimer formed between the pro peptide and the mature chain. The active enzyme has low activity against peptide substrates tested, but high activity against thioester substrates. The peptidase activity is inhibited by 20 mM benzamidine.

1. Bhagwandin, V.J. et al. (2003) J. Biol. Chem. 278:3363.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.