MAP3K8/Tpl2/COT RNAi

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications RNAi, RNAi SP

Order Details

MAP3K8/Tpl2/COT RNAi Summary

Specificity
mitogen-activated protein kinase kinase kinase 8 (MAP3K8), mRNA
Gene
MAP3K8

Applications/Dilutions

Application Notes
This RNAi causes protein knockdown.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for MAP3K8/Tpl2/COT RNAi

  • Cancer Osaka thyroid oncogene
  • c-COT
  • cot (cancer Osaka thyroid) oncogene
  • COT
  • COTMEKK8
  • EC 2.7.11.25
  • EST
  • ESTF
  • ESTFLJ10486
  • Ewing sarcoma transformant
  • MAP3K8
  • mitogen-activated protein kinase kinase kinase 8
  • Proto-oncogene c-Cot
  • proto-oncogene serine/threoine protein kinase
  • Serine/threonine-protein kinase cot
  • TPL2
  • Tpl-2
  • Tumor progression locus 2
  • tumor progression locus-2

Background

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. RNAi are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol MAP3K8
Entrez