MAP3K8/Tpl2/COT Products

Antibodies
MAP3K8/Tpl2/COT Antibody
MAP3K8/Tpl2/COT Antibody
NBP1-62178
Species: Hu, Mu, Rt
Applications: WB, DB, ELISA, IP
Host: Rabbit Polyclonal
Conjugate Catalog # Availability Size Price
MAP3K8/Tpl2/COT Antibody
MAP3K8/Tpl2/COT Antibody
NBP1-86569
Species: Hu, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MAP3K8/Tpl2/COT Antibody (634 ...
MAP3K8/Tpl2/COT Antibody (634130)
MAB4586
Species: Hu
Applications: WB
Host: Mouse Monoclonal
Lysates
MAP3K8/Tpl2/COT Overexpressio ...
MAP3K8/Tpl2/COT Overexpression Lys...
NBL1-12859
Applications: WB
Proteins
MAP3K8/Tpl2/COT Recombinant P ...
MAP3K8/Tpl2/COT Recombinant Protein
H00001326-P01
Species: Hu
Applications: WB, ELISA, PA
MAP3K8/Tpl2/COT Partial Recom ...
MAP3K8/Tpl2/COT Partial Recombinan...
H00001326-Q01
Species: Hu
Applications: WB, ELISA, PA
MAP3K8/Tpl2/COT Recombinant P ...
MAP3K8/Tpl2/COT Recombinant Protei...
NBP1-86569PEP
Species: Hu
Applications: AC
RNAi
MAP3K8/Tpl2/COT RNAi
MAP3K8/Tpl2/COT RNAi
H00001326-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

The role of mitogen-activated protein kinases (MAPKs) in cell signaling pathways is well established. The rat gene Tpl-2, for tumor progression locus 2, and the human and mouse homologues c-Cot, for cancer osaka thyroid oncogene, encode a proto-oncogene serine/threonine protein kinase that was shown to play a role in the functional activation of the MAP kinase pathway. Overexpression of Cot induces MAP kinase activation in COS-1 and NIH/3T3 cells. Cot-mediated activation of MAP kinase is inhibited by both Ras N17, a dominant negative mutant of c-H-Ras, and Raf-1s621A, a dominant negative mutant of Raf-1, suggesting that Cot functions upstream of Ras and Raf-1.Other studies have shown that a kinase-negative, dominant negative mutant of Cot partially blocks Ras or Raf-1-induced MAP kinase activation, arguing that Cot functions downstream of Ras and Raf-1. To explain these contrasting findings, it has been suggested that Cot, Ras and Raf-1 may form a multimeric complex that phosphorylates MEK-1. Cot has also been shown to be implicated in T lymphocyte activation.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 1326
Alternate Names
  • Cancer Osaka thyroid oncogene
  • TPL-2
  • ESTF
  • EC 2.7.11.25
  • Tumor progression locus 2
  • tumor progression locus-2
  • Serine/threonine-protein kinase cot
  • proto-oncogene serine/threoine protein kinase
  • Proto-oncogene c-Cot
  • Ewing sarcoma transformant
  • c-COT
  • cot (cancer Osaka thyroid) oncogene
  • Tpl-2
  • COTMEKK8
  • ESTFLJ10486
  • TPL2
  • mitogen-activated protein kinase kinase kinase 8

Research Areas for MAP3K8/Tpl2/COT

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Phospho-Specific
Protein Kinase

PTMs for MAP3K8/Tpl2/COT

Learn more about PTMs related to MAP3K8/Tpl2/COT.

Phosphorylation
Cleavage
Dephosphorylation
Ubiquitination
Reduction
Acetylation
Methylation

Bioinformatics Tool for MAP3K8/Tpl2/COT

Discover related pathways, diseases and genes to MAP3K8/Tpl2/COT. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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