Recombinant Human Lysyl tRNA synthetase Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human Lysyl tRNA synthetase Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 63-597 of Human Lysyl tRNA synthetase

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSGVGPEEE SVDPNQYYKI RSQAIHQLKV NGEDPYPHKF HVDISLTDFI QKYSHLQPGD HLTDITLKVA GRIHAKRASG GKLIFYDLRG EGVKLQVMAN SRNYKSEEEF IHINNKLRRG DIIGVQGNPG KTKKGELSII PYEITLLSPC LHMLPHLHFG LKDKETRYRQ RYLDLILNDF VRQKFIIRSK IITYIRSFLD ELGFLEIETP MMNIIPGGAV AKPFITYHNE LDMNLYMRIA PELYHKMLVV GGIDRVYEIG RQFRNEGIDL THNPEFTTCE FYMAYADYHD LMEITEKMVS GMVKHITGSY KVTYHPDGPE GQAYDVDFTP PFRRINMVEE LEKALGMKLP ETNLFETEET RKILDDICVA KAVECPPPRT TARLLDKLVG EFLEVTCINP TFICDHPQIM SPLAKWHRSK EGLTERFELF VMKKEICNAY TELNDPMRQR QLFEEQAKAK AAGDDEAMFI DENFCTALEY GLPPTAGWGM GIDRVAMFLT DSNNIKEVLL FPAMKPEDKK ENVATTDTLE STTVGTSV

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
KARS
Purity
>95% pure by SDS-PAGE

Applications/Dilutions

Theoretical MW
63.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl, 1mM DTT
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Human Lysyl tRNA synthetase Protein

  • CMTRIB
  • EC 6.1.1
  • EC 6.1.1.6
  • KARS2
  • KIAA0070
  • KRS
  • lysine tRNA ligase
  • Lysine--tRNA ligase
  • lysRS
  • lysyl-tRNA synthetase

Background

KARS, also known as Lysyl-tRNA synthetase, belongs to the class-II aminoacyl-tRNA synthetase family. It exists as both mitochondrial and cytoplasmic isoforms produced by alternative splicing, and thought to play a role in autoimmune diseases, such as polymyositis or dermatomyositis. This protein functions to catalyze the aminoacylation of tRNAs by their corresponding amino acids, thus linking amino acids with tRNA-contained nucleotide triplets. Recombinant human KARS protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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FAQs for Lysyl tRNA synthetase Protein (NBP1-72410). (Showing 1 - 1 of 1 FAQ).

  1. I was wondering if your Lysyl tRNA synthetase Protein (NBP1-72410) is active or not? I'm looking to use active human tRNA synthetase for an experiment. Thank you.
    • Unfortunately, this protein lysate has never been tested in any functional assay. Furthermore, this protein was linked to a His-tag and produced in E. coli, where there has no proper post-translation modification that could render the functional protein product. Therefore, we do not beleive that this protein may have functional activity.

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Bioinformatics

Gene Symbol KARS