Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody [Alexa Fluor™ Plus 555]

• Reactivity: Hu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 555

Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody [Alexa Fluor™ Plus 555] Summary

• Specificity: Detects human Lysine (K)-specific Demethylase 6B/KDM6B in direct ELISAs.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody [Alexa Fluor™ Plus 555]

• EC 1.14.11
• EC 1.14.11.-
• JmjC domain-containing protein 3
• JMJD3
• JMJD3lysine-specific demethylase 6B
• jumonji domain containing 3, histone lysine demethylase
• Jumonji domain-containing protein 3
• KDM6B
• KIAA0346jumonji domain containing 3
• Lysine (K)specific Demethylase 6B
• Lysine (K)-specific Demethylase 6B
• Lysine demethylase 6B

Background

KDM6B (Lysine [K]-specific demethylase 6B; also JMJD3) is a 170-185 kDa member of the UTX family of enzymes. It is expressed in both embryo and adult, and specifically demethylates tri- and di-methylated Lys27 on histone H3 (H3K27). Methylation of H3K27 by PRC2 inactivates genes, while demethylation of methylated H3K27 by KDM6B activates genes. Human KDM6B is 1643 amino acids (aa) in length. It contains two Pro-rich regions (aa 32-85 and 1046-1082) plus one jumonji domain (aa 1339-1502). One potential splice variant is reported that contains a 39 aa insertion after Leu1636. Over aa 1530-1682, which is a sequence that contains the 39 aa insertion, human KDM6B shares 75% aa sequence identity with mouse KDM6B. When the insertion is disregarded, human and mouse KDM6B are identical in aa sequence over the above range of amino acids.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.