LYPD1 Antibody [Alexa Fluor® 700]

• Applications: IHC
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 700

LYPD1 Antibody [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human LYPD1
  Cys54-Ser116
  Accession # Q8N2G4
• Specificity: Detects human LYPD1 in direct ELISAs. In direct ELISAs, less than 1% cross-reactivity with recombinant human LYPD3 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

LYPD1 (Ly6/PLAUR-domain containing protein 1; also Lynx2 and PHTS) is a 15-20 kDa member of the Ly6 family of GPI-anchored proteins. It is expressed on postmitotic neurons in multiple locations, performing multiple functions. Two suggested functions include the ability to 1) block cell proliferation, and 2) bind to acetylcholine receptors, promoting their desensitization. Human LYPD1 preproprecursor is 141 amino acids (aa) in length. It contains a signal sequence (aa 1-20), a 97 aa mature region (aa 21-117), and a cleavable prodomain that, when cleaved, generates a GPI-linked form (aa 118-141). The mature molecule contains one Ly6 domain (aa 25-107). There are multiple potential isoform variants. One possesses an alternative start site at Met53, a second contains a 21 aa substitution for aa 1-5, a third shows a 21 aa substitution for aa 64-141, and a fourth possesses a 29 aa substitution for aa 65-141. Over aa 54-116, human and mouse LYPD1 are identical in aa sequence.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.