LRP-1 Antibody (Alpha 2MR alpha-2)

Immunohistochemistry-Paraffin: Low Density LRP Antibody (Alpha 2MR alpha-2) [NBP1-40121] - Analysis of anti-LRP1 / Low Density LRP antibody with human liver at concentration 10 ug/ml.

Product Discontinued

LRP-1 Antibody (Alpha 2MR alpha-2) Summary

• Immunogen: Purified alpha 2 macroglobulin receptor.
• Specificity: Recognizes human CD91, a type I membrane protein which is also known as the alpha 2 macroglobulin receptor (alpha 2 MR). Recognizes an epitope in the extracellular region of the 500kD alpha chain.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: LRP1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100 - 1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:10 - 1:500
  • Immunohistochemistry-Paraffin 5-10 ug/ml
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for LRP-1 Antibody (Alpha 2MR alpha-2)

• A2MR
• Alpha-2-Macroglobulin Receptor
• APOER
• Apolipoprotein E receptor
• APR
• CD91 antigen
• CD91
• EC 1.1.1.94
• EC 3.4.21.9
• IGFBP3R
• low density lipoprotein receptor-related protein 1
• LRP
• LRP-1
• LRP1A
• prolow-density lipoprotein receptor-related protein 1
• TbetaR-V/LRP-1/IGFBP-3 receptor
• TGFBR5
• type V tgf-beta receptor

Background

Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LRP1
• Entrez:
  • 4035(Human)
• Uniprot:
  • Q07954(Human)