Lnx1 Antibody

Western Blot: Lnx1 Antibody [H00084708-B01P] - Analysis of LNX1 expression in transfected 293T cell line by LNX1 polyclonal antibody. Lane 1: LNX1 transfected lysate(69.52 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

Lnx1 Antibody Summary

• Immunogen: LNX1 (AAH34737.1, 1 a.a. - 632 a.a.) full-length human protein. MKALLLLVLPWLSPANYIDNVGNLHFLYSELCKGASHYGLTKDRKRRSQDGCPDGCASLTATAPSPEVSAAATISLMTDEPGLDNPAYVSSAEDGQPAISPVDSGRSNRTRARPFERSTIRSRSFKKINRALSVLRRTKSGSAVANHADQGRENSENTTAPEVFPRLYHLIPDGEITSIKINRVDPSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVNGMDISNVPHNYAVRLLRQPCQVLWLTVMREQKFRSRNNGQAPDAYRPRDDSFHVILNKSSPEEQLGIKLVRKVDEPGVFIFNVLDGGVAYRHGQLEENDRVLAINGHDLRYGSPESAAHLIQASERRVHLVVSRQVRQRSPDIFQEAGWNSNGSWSPGPGERSNTPKPLHPTITCHEKVVNIQKDPGESLGMTVAGGASHREWDLPIYVISVEPGGVISRDGRIKTGDILLNVDGVELTEVSRSEAVALLKRTSSSIVLKALEVKEYEPQEDCSSPAALDSNHNMAPPSDWSPSWVMWLELPRCLYNCKDIVLRRNTAGSLGFCIVGGYEEYNGNKPFFIKSIVEGTPAYNDGRIRCGDILLAVNGRSTSGMIHACLARLLKELKGRITLTIVSWPGTFL
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: LNX1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Functional
  • Western Blot
• Application Notes: This antibody is useful for Western Blot, Functional

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Lnx1 Antibody

• EC 6.3.2.-
• ligand of numb-protein X 1ligand of numb-protein X
• LNXmulti-PDZ-domain-containing protein, E3 ubiquitin-protein ligase LNX
• MPDZ
• Numb-binding protein 1
• PDZ domain-containing ring finger protein 2
• PDZRN2E3 ubiquitin-protein ligase LNX

Background

Lnx1 encodes a membrane-bound protein that is involved in signal transduction and protein interactions. The encoded product is an E3 ubiquitin-protein ligase, which mediates ubiquitination and subsequent proteasomal degradation of proteins containing phosphotyrosine binding (PTB) domains. This protein may play an important role in tumorogenesis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene, which is located on chromosome 17, has been identified for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Lnx1 Antibody (H00084708-B01P)(1)

Publication using H00084708-B01P

• Nayak D, Sivaraman J., et al. Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1. J Mol Biol 2018-02-26 [PMID: 29496391]

Bioinformatics

• Gene Symbol: LNX1
• Uniprot:
  • AAH34737.1(Human)