Latrophilin 3/LPHN3 Antibody - BSA Free

Immunohistochemistry-Paraffin: Latrophilin 3/LPHN3 Antibody [NLS1138] - Analysis of anti-LPHN3 / Latrophilin-3 antibody with human brain, glioblastoma.

Immunohistochemistry-Paraffin: Latrophilin 3/LPHN3 Antibody [NLS1138] - Analysis of anti-LPHN3 / Latrophilin-3 antibody with brain neurons at 2 ug/ml.

• Reactivity: Hu, Mu, Rt, Bt, Ch, Eq, Pm, Pm, Rb, Av, Bv, Ma-Op
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

Latrophilin 3/LPHN3 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 19 amino acid peptide from C-terminus of human Latrophilin 3/LPHN3.
• Epitope: C-Terminus
• Localization: Plasma membrane
• Specificity: Human LPHN3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Bovine (95%), Opossum (100%), Avian (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ADGRL3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 2 ug/ml
• Application Notes: .

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (100%), Gibbon (89%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Latrophilin 3/LPHN3 Antibody - BSA Free

• CIRL3
• Latrophilin 3
• latrophilin homolog 3 (cow)
• LEC3
• Lectomedin-3
• LPHN3

Background

Latrophilin-3 is a brain-specific, Ca2+-independent Orphan-B Receptor with an unknown ligand. Unlike the other two latrophilins, Latrophilin-3 does not bind alpha-latrotoxin. Latrophilin-3, like its isoforms, shares homology with lectin, olfactomedin, and transmembrane domains, and possesses variable C-termini and various alternative-splicing sites. Latrophilin-3 has been reported in brain. ESTs have been isolated from B-cell/lung/testis, brain, ear, eye, heart, heart/melanocyte/uterus, kidney, lung, nerve, placenta, and testis libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Latrophilin 3/LPHN3 Antibody (NLS1138)(3)

Publications using NLS1138

• Arcos-Burgos M, Jain M, Acosta MT et al. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry 2010-11-01 [PMID: 20157310] (IF/IHC, Human)
• Lux TJ Characterization of Junctional Proteins in the Dorsal Root Ganglion of Rats with Traumatic Nerve Injury Thesis 2022-01-01 (WB, IF/IHC, Rat)
• Singh J, Elhabashy H, Muthukottiappan P et al. Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo Nature communications 2022-10-20 [PMID: 36266287] (IP, Human)

Bioinformatics

• Gene Symbol: ADGRL3
• Entrez:
  • 23284(Human)
• Uniprot:
  • Q9HAR2(Human)