Latrophilin 2/LPHN2 Antibody

Immunohistochemistry-Paraffin: Latrophilin 2/LPHN2 Antibody [NLS1132] - Anti-LPHN2 / Latrophilin-2 antibody IHC of human prostate, smooth muscle, benign prostatic hyperplasia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: Latrophilin 2/LPHN2 Antibody [NLS1132] - Analysis of anti-LPHN2 / Latrophilin-2 antibody with brain (neurons and glia) using this antibody at 18 ug/ ml.

Immunohistochemistry-Paraffin: Latrophilin 2/LPHN2 Antibody [NLS1132] - Analysis of anti-LPHN2 / Latrophilin-2 antibody with human prostate, carcinoma.

Product Discontinued

Latrophilin 2/LPHN2 Antibody Summary

• Immunogen: Synthetic 16 amino acid peptide from N-terminal extracellular domain of human Latrophilin 2/LPHN2.
• Specificity: Human LPHN2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Mouse (94%), Monkey (100%), Primate (94%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: LPHN2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 18 - 45 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gibbon (100%), Gorilla (94%), Marmoset (94%), Rat (88%), Canine (88%), Bovine (81%), Equine (81%), Rabbit (81%), Porcine (81%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Latrophilin 2/LPHN2 Antibody

• ADGRL2
• Calcium-independent alpha-latrotoxin receptor 2
• CIRL2
• CIRL-2
• CL2
• KIAA0786
• Latrophilin 2
• Latrophilin homolog 1
• latrophilin homolog 2 (cow)
• latrophilin-2
• LEC1
• LEC1LPHH1latrophilin 1
• lectomedin-1
• LPHH1
• LPHN2

Background

Latrophilin-2 is an Orphan-B Receptor that binds alpha-latrotoxin, a potent presynaptic neurotoxin present in the venom of the black widow spider, in a Ca2+-independent manner. As with the other two latrophilins, it shares homology with lectin, olfactomedin, and transmembrane domains, and possesses variable C-termini and various alternative-splice sites. Latrophilin-2 is endoproteolytically cleaved at the end of the GPS domain, and the two subunits remain non-covantely linked as a heterodimer. Latrophilin-2 has been reported to be expressed in brain, breast, placenta, kidney, spleen, ovary, heart, and lung. ESTs have been isolated from a wide variety of tissue libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LPHN2
• Entrez:
  • 23266(Human)
• Uniprot:
  • O95490()