Latrophilin 2/LPHN2 Antibody (1030202) [Janelia Fluor® 585]

Product Discontinued

Latrophilin 2/LPHN2 Antibody (1030202) [Janelia Fluor® 585] Summary

• Immunogen: Human Latrophilin 2/LPHN2 synthetic peptide
  Accession # O95490
• Specificity: Detects human Latrophilin 2/LPHN2 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for Latrophilin 2/LPHN2 Antibody (1030202) [Janelia Fluor® 585]

• ADGRL2
• Calcium-independent alpha-latrotoxin receptor 2
• CIRL2
• CIRL-2
• CL2
• KIAA0786
• Latrophilin 2
• Latrophilin homolog 1
• latrophilin homolog 2 (cow)
• latrophilin-2
• LEC1
• LEC1LPHH1latrophilin 1
• lectomedin-1
• LPHH1
• LPHN2

Background

Latrophilin-2 is an Orphan-B Receptor that binds alpha-latrotoxin, a potent presynaptic neurotoxin present in the venom of the black widow spider, in a Ca2+-independent manner. As with the other two latrophilins, it shares homology with lectin, olfactomedin, and transmembrane domains, and possesses variable C-termini and various alternative-splice sites. Latrophilin-2 is endoproteolytically cleaved at the end of the GPS domain, and the two subunits remain non-covantely linked as a heterodimer. Latrophilin-2 has been reported to be expressed in brain, breast, placenta, kidney, spleen, ovary, heart, and lung. ESTs have been isolated from a wide variety of tissue libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.