LAMTOR1 Antibody - BSA Free

Immunohistochemistry-Paraffin: LAMTOR1 Antibody [NBP1-89909] - Staining of human prostate shows strong granular cytoplasmic positivity in glandular cells.

Immunohistochemistry-Paraffin: LAMTOR1 Antibody [NBP1-89909] - Staining of human duodenum shows strong granular cytoplasmic positivity in glandular cells.

Immunohistochemistry-Paraffin: LAMTOR1 Antibody [NBP1-89909] - Staining of human skin shows strong positivity in cytoplasm granular in squamous epithelial cells.

Immunohistochemistry-Paraffin: LAMTOR1 Antibody [NBP1-89909] - Staining of human tonsil shows strong positivity in cytoplasm granular in non-germinal center cells.

• Reactivity: Hu, Mu, Rt
• Applications: ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

LAMTOR1 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit LAMTOR1 Antibody - BSA Free (NBP1-89909) is a polyclonal antibody validated for use in IHC and ICC/IF. Anti-LAMTOR1 Antibody: Cited in 5 publications. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: NEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVV
• Predicted Species: Mouse (99%), Rat (97%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: LAMTOR1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:500 - 1:1000
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF reactivity reported in (PMID: 30428163).
• Control Peptide:

  LAMTOR1 Recombinant Protein Antigen (NBP1-89909PEP)

Reactivity Notes

Reactivity reported in scientific literature (PMID: 22576015)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for LAMTOR1 Antibody - BSA Free

• c11orf59
• chromosome 11 open reading frame 59
• FLJ20625
• LAMTOR1
• Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1
• late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
• Lipid raft adaptor protein p18
• p18
• p27kip1 releasing factor from RhoA
• p27Kip1-releasing factor from RhoA
• p27RF-RhoC11orf59
• PDRO
• PDROPdro
• Protein associated with DRMs and endosomes
• ragulator complex protein PDRO
• Ragulator1
• RhoA activator C11orf59

Background

Activates RHOA. Binds to CDKN1B and prevents interaction of CDKN1B and RHOA. This leaves RHOA in a form accessible to ARHGEF2, thereby promoting ARHGEF2-mediated exchange of GDP for GTP

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for LAMTOR1 Antibody (NBP1-89909)(5)

Publications using NBP1-89909

• Lin C, Nozawa T, Minowa-Nozawa A et al. LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy. Cellular Microbiology. 2018-11-14 [PMID: 30428163] (ICC/IF, Human)
• Munson MJ, Allen GF, Toth R et al. mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival. EMBO J 2015-09-02 [PMID: 26139536] (ICC/IF, Human)
• Martina JA, Chen Y, Gucek M, Puertollano R. MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy 2012-06-01 [PMID: 22576015]
• Taub N, Nairz M, Hilber D et al. The late endosomal adaptor p14 is a macrophage host-defense factor against Salmonella infection. J Cell Sci 2012-06-01 [PMID: 22427693]
• de Mateo S, Castillo J, Estanyol JM et al. Proteomic characterization of the human sperm nucleus. PROTEOMICS 2011-06-01 [PMID: 21080497]

Bioinformatics

• Gene Symbol: LAMTOR1