Kv7.4 Antibody

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Western Blot: Kv7.4 Antibody [NB100-93448] - Analysis of Kv7.4 in Cerebellum lysate (35ug protein in RIPA buffer) using NB100-93448 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Kv7.4 Antibody Summary

Immunogen
Peptide with sequence C-DKGPSDAEVVDE corresponding to internal region according to NP_004691.2, NP_751895.1.
Epitope
C-DKGPSDAEVVDE
Specificity
This antibody is expected to recognise both reported isoforms (NP_004691.2; NP_751895.1); may cross-react in Mouse;
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
KCNQ4
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1 - 3 ug/ml
  • Peptide ELISA Detection limit 1:4000
Application Notes
WB: Approx. 70 kDa band observed in human brain (cerebellum) lysates (calculated MW of 71.2 kDa band according to NP_751895.1).
Positive Control
Kv7.4 Lysate (NBL1-12200)
Publications
Read Publication using NB100-93448.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Kv7.4 Antibody

  • DFNA2
  • DFNA2A
  • KQT-like 4
  • Kv7.4
  • potassium channel KQT-like 4
  • Potassium channel subunit alpha KvLQT4
  • potassium voltage-gated channel subfamily KQT member 4
  • potassium voltage-gated channel, KQT-like subfamily, member 4
  • Voltage-gated potassium channel subunit Kv7.4

Background

The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Kv7.4 Antibody (NB100-93448)(1)

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Product General Protocols

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol KCNQ4
Entrez
Uniprot