Kv7.3 Antibody

• Reactivity: Hu, Mu, Rt
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

Kv7.3 Antibody Summary

• Description: Novus Biologicals Rabbit Kv7.3 Antibody (NBP2-80515) is a polyclonal antibody validated for use in IHC and WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: A synthetic peptide from amino acid region 60-120 of mouse Kv7.3 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in human and rat.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNQ3
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:2000
  • Immunohistochemistry-Paraffin 1:200 - 1:2000
  • Western Blot 1:200 - 1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from whole serum
• Preservative: No Preservative
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Alternate Names for Kv7.3 Antibody

• BFNC2
• EBN2
• KCNQ3
• KQT-like 3
• Kv7.3
• Potassium channel subunit alpha KvLQT3
• potassium channel, voltage-gated, subfamily Q, member 3
• potassium voltage-gated channel subfamily KQT member 3
• potassium voltage-gated channel, KQT-like subfamily, member 3
• Voltage-gated potassium channel subunit Kv7.3

Background

KCNQ3 is a gene that codes for a protein with two isoforms, measuring 872 and 752 amino acids in length, with weights of approximately 97 and 85 kDa respectively. KCNQ3 is thought to be important in the regulation of neuronal excitability. Current studies are being done one several diseases and disorders linked to this gene including convulsions, myokymia with neonatal epilepsy, juvenile myoclonic epilepsy, generalized epilepsy, benign neonatal seizures, neuronitis, migraine, pharyngitis, and ataxia. KCNQ3 has also been shown to have interactions with CALM1, CALM2, CALM3, KCNQ4, and KCNQ2 in pathways such as the synaptic transmission-ion currents, L1CAM interactions, potassium channels, and celecoxib pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNQ3