Kv1.2 Antibody [DyLight 488]

Product Discontinued

Kv1.2 Antibody [DyLight 488] Summary

• Immunogen: Synthetic peptide made to a portion of rat Kv1.2 (within residues 50-100). [Swiss-Prot: P63142]
• Localization: Membrane; Multi-pass membrane protein
• Specificity: Does not cross-react with Kv3.1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNA2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Kv1.2 Antibody [DyLight 488]

• EC 3.6.1.27
• EC 6.1.1
• HBK5
• HK4
• HUKIV
• KCNA2
• Kv1.2
• MGC50217
• MK2
• NGK1
• potassium channel
• potassium voltage-gated channel subfamily A member 2
• potassium voltage-gated channel, shaker-related subfamily, member 2
• RBK2
• Voltage-gated K(+) channel HuKIV
• Voltage-gated potassium channel HBK5
• voltage-gated potassium channel protein Kv1.2
• Voltage-gated potassium channel subunit Kv1.2

Background

KCNA2 (Potassium voltage-gated channel subfamily A member 2) mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which K(+) ions may pass in accordance with their electrochemical gradient. KCNA2 binds PDZ domains of DLG1, DLG2 and DLG4. The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNA2