Kv1.2 Antibody

Images

 
Immunocytochemistry/ Immunofluorescence: Kv1.2 Antibody [NBP1-42802] - Detection of Kv1.2 (Green) in 293 human embryonic kidney cells using NBP1-42802. Nuclei (Blue) are counterstained using Hoechst 33258.

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Bv, Ca, Xp, ZeSpecies Glossary
Applications WB, ICC/IF, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Kv1.2 Antibody Summary

Immunogen
Synthetic peptide made to a portion of rat Kv1.2 (within residues 50-100). [Swiss-Prot# P63142]
Localization
Membrane; Multi-pass membrane protein
Specificity
Does not cross-react with Kv3.1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
KCNA2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunocytochemistry/Immunofluorescence 1:250-1:500
  • Immunoprecipitation 1:10-1:500
Application Notes
This Kv1.2 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Western blot, where a band can be seen at ~80 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
80 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NBP1-42802 in the following applications:

  • 1 publication
  • IP
    1 publication
  • WB
    2 publications

Reactivity Notes

Human, mouse, rat, bovine, porcine, canine, Xenopus, Zebrafish and other vertebrates.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Kv1.2 Antibody

  • EC 3.6.1.27
  • EC 6.1.1
  • HBK5
  • HK4
  • HUKIV
  • KV1.2
  • MGC50217
  • MK2
  • NGK1
  • potassium channel
  • potassium voltage-gated channel subfamily A member 2
  • potassium voltage-gated channel, shaker-related subfamily, member 2
  • RBK2
  • Voltage-gated K(+) channel HuKIV
  • Voltage-gated potassium channel HBK5
  • voltage-gated potassium channel protein Kv1.2
  • Voltage-gated potassium channel subunit Kv1.2

Background

Kv1.2 (KCNA2, Potassium voltage-gated channel subfamily A member 2) mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which K(+) ions may pass in accordance with their electrochemical gradient. Kv1.2 binds PDZ domains of DLG1, DLG2 and DLG4. The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Kv1.2 Antibody (NBP1-42802)(2)

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 3 applications: ICC/IF, IP, WB.


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ICC/IF
(1)
IP
(1)
WB
(2)
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Human
(1)
Rat
(1)
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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Kv1.2 Antibody (NBP1-42802) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-42802AF405
Alexa Fluor 488 Labeled NBP1-42802AF488
Alexa Fluor 647 Labeled NBP1-42802AF647
Alexa Fluor 700 Labeled NBP1-42802AF700
Biotin Labeled NBP1-42802B
DyLight 405 Labeled NBP1-42802V
DyLight 488 Labeled NBP1-42802G
DyLight 550 Labeled NBP1-42802R
DyLight 650 Labeled NBP1-42802C
FITC Labeled NBP1-42802F
HRP Labeled NBP1-42802H

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Bioinformatics

Gene Symbol KCNA2
Entrez
Uniprot