Kv1 Antibody [Alexa Fluor® 488]

Product Discontinued

Kv1 Antibody [Alexa Fluor® 488] Summary

• Immunogen: Synthetic peptide made to rat Kv1.2 (within residues 50-100), which is identical in all members of the Kv1 family.
• Localization: Membrane; Multi-pass membrane protein
• Specificity: Reacts with all members of the Kv1 family. Does not cross-react with Kv3.1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: KCNA2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: This Kv1 antibody is useful for Immunoprecipitation and Western blot, where a band can be seen at ~80 kDa.
  
  The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, mouse, rat, bovine, porcine, canine, Xenopus, Zebrafish and other vertebrates.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Kv1 Antibody [Alexa Fluor® 488]

• potassium channel
• shaker-related subfamily
• voltage-gated potassium channel

Background

Kv1 is a subfamily (also called the Shaker family) of voltage-gated potassium channels containing at least seven members. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. The Kv1 subfamily may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KCNA2