Kallikrein 6/Neurosin Antibody (265508)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clone
265508
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

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Catalog# & Formulation Size Price

Kallikrein 6/Neurosin Antibody (265508) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Kallikrein 6/Neurosin
Leu22-Lys244
Accession # Q92876
Specificity
Detects human Kallikrein 6/Neurosin in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human (rh) Factor X, recombinant mouse HGFA, rhKLK3, 4, 5, 8, 10, 11, 15, rhThrombin, or rhuPA is observed.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
KLK6
Purity
Protein A or G purified from hybridoma culture supernatant
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL
Publications
Read Publications using
MAB2008 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Kallikrein 6/Neurosin Antibody (265508)

  • Bssp
  • EC 3.4.21
  • EC 3.4.21.-
  • hK6
  • kallikrein 6 (neurosin, zyme)
  • Kallikrein 6
  • kallikrein-6
  • kallikrein-related peptidase 6
  • KLK6
  • Klk7
  • Neurosin
  • Protease M
  • protease, serine, 18
  • PRSS18
  • PRSS9
  • PRSS9MGC9355
  • Serine protease 18
  • Serine protease 9
  • SP59
  • Zyme

Background

Tissue kallikreins are a family of extracellular serine proteases consisting of 15 members (1, 2). The genes of this family aligned in tandem on chromosome 19q13.4 represent the largest contiguous group of proteases within the human genome. Tissue kallikreins have attracted great interest as potential biomarkers for various cancers, including prostate, ovarian, breast, testicular, and lung (2, 3). Human Kallikrein 6 (KLK6) is a member of tissue kallikrein family observed in breast and brain tissues, colon carcinoma cells, and oligodedrocytes (1‑3). Known protein substrates of KLK6 are myelin basic protein, the precursor of the A beta amyloid peptide, and plasminogen. Its physiological functions may include the participation in demyelination processes as well as in the progression of inflammatory disease of the CNS. The level of KLK6 is reduced in brain extracts of Alzheimer patients and increased in serum of patients with ovarian cancer.

  1. Emami, N. and E.P. Diamandis (2007) Clin Chim Acta 381:78.
  2. Borgoño, C.A. and E.P. Diamandis (2004) Nat. Rev. Cancer, 4:876.
  3. Paliouras, M. et al. (2007) Cancer Lett. 249:61.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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MAB2008
Species: Hu
Applications: WB, IP

Publications for Kallikrein 6/Neurosin Antibody (MAB2008)(4)

We have publications tested in 2 confirmed species: Human, Mouse.

We have publications tested in 3 applications: ELISA Development, Neutralization, Western Blot.


Filter By Application
ELISA Development
(1)
Neutralization
(1)
Western Blot
(2)
All Applications
Filter By Species
Human
(3)
Mouse
(1)
All Species

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol KLK6
Uniprot