IgM Antibody (MA2)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Clone
MA2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

IgM Antibody (MA2) Summary

Immunogen
IgM from human serum.
Specificity
Mu-chain of human IgM, Fab - region localized epitope.
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
IGHM
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
Application Notes
ELISA Optimal dilutions and concentrations should be determined by the end user.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein A purified

Alternate Names for IgM Antibody (MA2)

  • AGM1
  • DKFZp686I15196
  • DKFZp686I15212
  • FLJ00385
  • IgM
  • immunoglobulin heavy constant mu
  • MGC104996
  • MGC52291
  • MU
  • VH

Background

IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and is largely confined to plasma due to it's large size. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. Due to it's high valency IgM is more efficient than other isotypes is binding antigens with repeating epitopes (virus particles and red blood cells) and is more efficient than IgG in activiating the complement pathway. The gene for the mu constant region contains four domains separated by short intervening sequences. IgM measurement yields information about the body's immediate resistance and response to infection as well as information related to specific diseases. Decreased levels are associated with immune deficiency states, hereditary deficiencies, and myeloma. Increased levels can be associated with Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

Additional IgM Products

Bioinformatics Tool for IgM Antibody (NB110-7092)

Discover related pathways, diseases and genes to IgM Antibody (NB110-7092). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for IgM Antibody (NB110-7092)

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Pathways for IgM Antibody (NB110-7092)

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Research Areas for IgM Antibody (NB110-7092)

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Blogs on IgM.

Understanding the Importance of Human IgG
Human IgG is a component of the immune system that protects the body from infection. It is the most abundantly found antibody isotype within the circulatory system of the human body. All antibody isotypes contain two heavy chains and two light chains...  Read full blog post.

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Calculators

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Bioinformatics

Gene Symbol IGHM
Entrez