IFN-alpha Antibody [Unconjugated]

• Reactivity: Hu
• Applications: B/N
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Unconjugated

IFN-alpha Antibody [Unconjugated] Summary

• Immunogen: Mixture of all recombinant human interferon alpha subtypes (IFNA2, IFNA8, IFNA10, IFNA1, IFNA21, IFNA5, IFNA14, IFNA17, IFNA7, IFNA6, IFNA4, IFNA16)
• Specificity: Binds to and blocks biological activity of all human interferon alpha subtypes
• Source: N/A
• Isotype: Serum
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: N/A

Applications/Dilutions

• Dilutions:
  • Neutralization

Packaging, Storage & Formulations

• Storage: After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).
• Buffer: Neat serum diluted in phosphate buffered saline (PBS)

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-alpha Antibody [Unconjugated]

• IFNA
• IFNA2
• IFNA2b
• IFNalpha
• IFN-alpha
• IFN-alphaA
• INFA2
• interferon alpha 2
• LeIF D

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IFN-alpha Antibody (31110-1)(1)

Publication using 31110-1

• Ka NL, Lim GY, Kim SS et al. Type I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer Cellular and molecular life sciences : CMLS 5/20/2022 [PMID: 35593921]
  
  Details:
  Fig. 3