IFN-alpha Antibody (RMMA-1) [Fluorescein]

• Reactivity: Mu
• Applications: Flow, IHC
• Clone: RMMA-1
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Fluorescein

IFN-alpha Antibody (RMMA-1) [Fluorescein] Summary

• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Rat

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.
• Buffer: Phosphate buffered saline (PBS) containing 1% BSA and 0.05% Kathon, pH 7.2
• Preservative: 0.05% Kathon

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-alpha Antibody (RMMA-1) [Fluorescein]

• IFNA
• IFNA2
• IFNA2b
• IFNalpha
• IFN-alpha
• IFN-alphaA
• INFA2
• interferon alpha 2
• LeIF D

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IFN-alpha Antibody (22100-3)(5)

Publications using 22100-3

• A Ram Lee, Jin Seok Woo, Seon-Yeong Lee, Yeon Su Lee, Jooyeon Jung, Chae Rim Lee et al. SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis Cell Communication and Signaling 2023-03-02 [PMID: 36864432]
• Lydia Kalafati, Ioannis Kourtzelis, Jonas Schulte-Schrepping, Xiaofei Li, Aikaterini Hatzioannou, Tatyana Grinenko et al. Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity Cell 2020-10-29 [PMID: 33125892] (Flow Cytometry, Mouse)
• D Tripathi, E Welch, SS Cheekatla, RK Radhakrish, S Venkatasub, P Paidipally, A Van, B Samten, KP Devalraju, VSK Neela, VL Valluri, C Mason, S Nelson, R Vankayalap Alcohol enhances type 1 interferon-? production and mortality in young mice infected with Mycobacterium tuberculosis PLoS Pathog., 2018-08-02;14(8):e1007174. 2018-08-02 [PMID: 30071107] (Flow Cytometry, Mouse)
• Lena M Kranz Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy Nature, 2016-06-01;534(7607):396-401. 2016-06-01 [PMID: 27281205] (Flow Cytometry, Mouse)
• Type I IFNs Regulate Inflammation, Vasculopathy, and Fibrosis in Chronic Cutaneous Graft-versus-Host Disease J Immunol, 2016-05-25;0(0):. 2016-05-25 [PMID: 27226090] (IHC-Fr, Mouse)