IFN-alpha Antibody (K9) [Unconjugated]

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Product Details

Summary
Reactivity PoSpecies Glossary
Applications B/N
Clone
K9
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

IFN-alpha Antibody (K9) [Unconjugated] Summary

Immunogen
Porcine IFN-alpha
Specificity
Neutralizes pig interferon alpha
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Endotoxin Note
<1.0 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Neutralization
Publications
Read Publications using
27100-1 in the following applications:

Packaging, Storage & Formulations

Storage
After receipt, this product should be kept at -20°C for retention of full activity. Do not store below -20°C.
Buffer
Supplied as a liquid
Preservative
No Preservative

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-alpha Antibody (K9) [Unconjugated]

  • IFNA
  • IFNA2
  • IFNA2b
  • IFNalpha
  • IFN-alpha
  • IFN-alphaA
  • INFA2
  • interferon alpha 2

Background

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.
  1. L'Haridon, R.M. et al. 1991, Hybridoma 10:35-47.
  2. Splichal, I. et al. 1994, Immunology Letters 43:203-208.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IFN-alpha Antibody (27100-1)(7)

We have publications tested in 1 confirmed species: Porcine.

We have publications tested in 1 application: ELISA Development.


Filter By Application
ELISA Development
(7)
All Applications
Filter By Species
Porcine
(7)
All Species
Showing Publications 1 - 7 of 7.
Publications using 27100-1 Applications Species
Miller LC, Zanella EL, Waters WR Cytokine protein expression levels in tracheobronchial lymph node homogenates of pigs infected with pseudorabies virus. Clin. Vaccine Immunol., 2010;17(5):728-34. 2010 [PMID: 20219878] (ELISA Development,, Porcine) ELISA Development Porcine
Alves MP, Neuhaus V, Guzylack-Piriou L, Ruggli N, McCullough KC, Summerfield A Toll-like receptor 7 and MyD88 knockdown by lentivirus-mediated RNA interference to porcine dendritic cell subsets. Gene Ther., 2007;14(10):836-44. 2007 [PMID: 17330086] (ELISA Development,, Porcine) ELISA Development Porcine
de Los Santos T, de Avila Botton S, Weiblen R, Grubman MJ The leader proteinase of foot-and-mouth disease virus inhibits the induction of beta interferon mRNA and blocks the host innate immune response. J. Virol., 2006;80(4):1906-14. 2006 [PMID: 16439546] (ELISA Development,, Porcine) ELISA Development Porcine
Balmelli C, Vincent IE, Rau H, Guzylack-Piriou L, McCullough K, Summerfield A Fc gamma RII-dependent sensitisation of natural interferon-producing cells for viral infection and interferon-alpha responses. Eur. J. Immunol., 2005;35(8):2406-15. 2005 [PMID: 16021600] (ELISA Development,, Porcine) ELISA Development Porcine
Lee SM, Schommer SK, Kleiboeker SB Porcine reproductive and respiratory syndrome virus field isolates differ in in vitro interferon phenotypes. Vet. Immunol. Immunopathol., 2004;102(3):217-31. 2004 [PMID: 15507307] (ELISA Development,, Porcine) ELISA Development Porcine
Bensaude E, Turner JL, Wakeley PR, Sweetman DA, Pardieu C, Drew TW, Wileman T, Powell PP Classical swine fever virus induces proinflammatory cytokines and tissue factor expression and inhibits apoptosis and interferon synthesis during the establishment of long-term infection of porcine vascular endothelial cells. J. Gen. Virol., 2004;85(0):1029-37. 2004 [PMID: 15039545] (ELISA Development,, Porcine) ELISA Development Porcine
Moraes MP, Chinsangaram J, Brum MC, Grubman MJ Immediate protection of swine from foot-and-mouth disease: a combination of adenoviruses expressing interferon alpha and a foot-and-mouth disease virus subunit vaccine. Vaccine, 2003;22(2):268-79. 2003 [PMID: 14615155] (ELISA Development,, Porcine) ELISA Development Porcine

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Secondary Antibodies

 

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Diseases for IFN-alpha Antibody (27100-1)

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Pathways for IFN-alpha Antibody (27100-1)

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Blogs on IFN-alpha.

STING in Innate Immunity and Cancer: What’s the Buzz About?
STING (STimulator of INterferon Genes protein) acts as a sensor of cytosolic DNA. Bacteria/Virus or self-derived DNA in the cytosol activates the STING pathway and promotes the production of type I interferons (IFN-alpha and IFN-beta). STING also...  Read full blog post.

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