Human sTfR Quantikine IVD ELISA Kit

Product Discontinued

Human sTfR Quantikine IVD ELISA Kit Summary

• Background: The Quantikine IVD Human sTfR Immunoassay is designed for the quantitative determination of soluble transferrin receptor (sTfR) concentrations in human serum and plasma as an aid in the diagnosis of Iron-Deficiency Anemia (IDA), especially for the differential diagnosis of IDA and Anemia of Chronic Disease (ACD). For In Vitro Diagnostic Use.
• Additional Information: This product has been discontinued.
• Specificity: Measures human sTfR levels in various samples
• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: TFRC

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Interference observed with other substances.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human sTfR Quantikine IVD ELISA Kit

• CD71 antigen
• CD71
• CD71TRFR
• p90
• T9
• TfR (Transferrin R)
• TfR (TransferrinR)
• TfR
• TFR1
• TFRC
• TR
• transferrin receptor (p90, CD71)
• transferrin receptor protein 1
• TRFR

Background

Transferrin receptors are transmembrane, homodimeric proteins that play a role in iron transport, uptake, and storage. TfR is an essential receptor, found on almost all cell types, regulated by intracellular iron concentration, and has a high affiinity for transferrin. Soluble TfR (sTfR) arises from the proteolysis of TfR into monomers that can be measured in plasma and serum. TfR2 has limited tissue distribution (hepatocytes and enterocytes), is regulated by the cell cycle, and binds transferrin poorly.

Publications for TfR (Transferrin R) (DTFR1)(23)

Publications using DTFR1

• E Lukaszyk, M Lukaszyk, E Koc-Zoraws, A Bodzenta-L, J Malyszko Fibroblast growth factor 23, iron and inflammation - are they related in early stages of chronic kidney disease? Arch Med Sci, 2016-03-17;13(4):845-850. 2016-03-17 [PMID: 28721153] (Human)
• K Wray, A Allen, E Evans, C Fisher, A Premawardh, L Perera, R Rodrigo, G Goonathila, L Ramees, C Webster, AE Armitage, AM Prentice, DJ Weatherall, H Drakesmith, SR Pasricha Hepcidin detects iron deficiency in Sri Lankan adolescents with a high burden of hemoglobinopathy: A diagnostic test accuracy study Am. J. Hematol, 2017-02-01;92(2):196-203. 2017-02-01 [PMID: 27883199] (Human)
• Cepeda-Lopez A, Allende-Labastida J, Melse-Boonstra A, Osendarp S, Herter-Aeberli I, Moretti D, Rodriguez-Lastra R, Gonzalez-Salazar F, Villalpando S, Zimmermann M The effects of fat loss after bariatric surgery on inflammation, serum hepcidin, and iron absorption: a prospective 6-mo iron stable isotope study. Am J Clin Nutr, 2016-08-24;104(4):1030-1038. 2016-08-24 [PMID: 27557657] (Human)
• Garcia-Valdes L, Campoy C, Hayes H, Florido J, Rusanova I, Miranda M, McArdle H The impact of maternal obesity on iron status, placental transferrin receptor expression and hepcidin expression in human pregnancy. Int J Obes (Lond), 2015-01-23;39(4):571-8. 2015-01-23 [PMID: 25614087] (Human)
• McDermid , Joann M, Hennig , Branwen, van der Sande , Marianne, Hill , Adrian V, Whittle , Hilton C, Jaye , Assan, Prentice , Andrew M Host iron redistribution as a risk factor for incident tuberculosis in HIV infection: an 11-year retrospective cohort study. BMC Infect Dis, 2013-01-29;13(0):48. 2013-01-29 [PMID: 23360117] (Human)
• Talbot NP, Lakhal S, Smith TG, Privat C, Nickol AH, Rivera-Ch M, Leon-Velarde F, Dorrington KL, Mole DR, Robbins PA Regulation of hepcidin expression at high altitude. Blood, 2011-11-30;119(3):857-60. 2011-11-30 [PMID: 22130801] (Human)
• Piperno A, Galimberti S, Mariani R Modulation of hepcidin production during hypoxia-induced erythropoiesis in humans in vivo: data from the HIGHCARE project. Blood, 2010-12-13;117(10):2953-9. 2010-12-13 [PMID: 21149632] (Human)
• Vazquez Lopez MA, Llamas MA, Galera R, Sanchez AR, Lendinez F, Gonzalez-Ripoll M, Diez J, Bonillo A Comparison between one and three doses a week of recombinant erythropoietin in very low birth weight infants. J Perinatol, 2010-08-05;31(0):118-24. 2010-08-05 [PMID: 20689518] (Human)
• Karl JP, Lieberman HR, Cable SJ, Williams KW, Young AJ, McClung JP Randomized, double-blind, placebo-controlled trial of an iron-fortified food product in female soldiers during military training: relations between iron status, serum hepcidin, and inflammation. Am. J. Clin. Nutr., 2010-05-05;92(1):93-100. 2010-05-05 [PMID: 20444958] (Human)
• McClung JP, Karl JP, Cable SJ, Williams KW, Nindl BC, Young AJ, Lieberman HR Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: effects on iron status, physical performance, and mood. Am. J. Clin. Nutr., 2009-05-27;90(1):124-31. 2009-05-27 [PMID: 19474138] (Human)
• McDermid JM, van der Loeff MF, Jaye A, Hennig BJ, Bates C, Todd J, Sirugo G, Hill AV, Whittle HC, Prentice AM Mortality in HIV infection is independently predicted by host iron status and SLC11A1 and HP genotypes, with new evidence of a gene-nutrient interaction. Am. J. Clin. Nutr., 2009-05-27;90(1):225-33. 2009-05-27 [PMID: 19474129] (Human)
• Hunt JR, Zito CA, Johnson LK Body iron excretion by healthy men and women. Am. J. Clin. Nutr., 2009-04-22;89(6):1792-8. 2009-04-22 [PMID: 19386738] (Human)
• Bateman AP, McArdle F, Walsh TS Time course of anemia during six months follow up following intensive care discharge and factors associated with impaired recovery of erythropoiesis. Crit. Care Med., 2009-06-01;37(6):1906-12. 2009-06-01 [PMID: 19384207] (Human)
• Sun Q, Ma J, Rifai N, Franco OH, Rexrode KM, Hu FB Excessive body iron stores are not associated with risk of coronary heart disease in women. J. Nutr., 2008-12-01;138(12):2436-41. 2008-12-01 [PMID: 19022969] (Human)
• Ma AG, Schouten EG, Zhang FZ, Kok FJ, Yang F, Jiang DC, Sun YY, Han XX Retinol and riboflavin supplementation decreases the prevalence of anemia in chinese pregnant women taking iron and folic Acid supplements. J. Nutr., 2008-10-01;138(10):1946-50. 2008-10-01 [PMID: 18806105] (Human)
• Atkinson SH, Rockett KA, Morgan G, Bejon PA, Sirugo G, O'Connell MA, Hanchard N, Kwiatkowski DP, Prentice AM Tumor necrosis factor SNP haplotypes are associated with iron deficiency anemia in West African children. Blood, 2008-08-20;112(10):4276-83. 2008-08-20 [PMID: 18716131] (Human)
• Tanno T, Bhanu NV, Oneal PA, Goh SH, Staker P, Lee YT, Moroney JW, Reed CH, Luban NL, Wang RH, Eling TE, Childs R, Ganz T, Leitman SF, Fucharoen S, Miller JL High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat. Med., 2007-08-26;13(9):1096-101. 2007-08-26 [PMID: 17721544] (Human)
• Swain JH, Johnson LK, Hunt JR Electrolytic iron or ferrous sulfate increase body iron in women with moderate to low iron stores. J. Nutr., 2007-03-01;137(3):620-7. 2007-03-01 [PMID: 17311950] (Human)
• Ghio AJ, Turi JL, Madden MC, Dailey LA, Richards JD, Stonehuerner JG, Morgan DL, Singleton S, Garrick LM, Garrick MD Lung injury after ozone exposure is iron dependent. Am. J. Physiol. Lung Cell Mol. Physiol., 2006-08-11;292(1):L134-43. 2006-08-11 [PMID: 16905637] (Human)
• Chen YC, Hung SC, Tarng DC Association between transferrin receptor-ferritin index and conventional measures of iron responsiveness in hemodialysis patients. Am. J. Kidney Dis., 2006-06-01;47(6):1036-44. 2006-06-01 [PMID: 16731299] (Human)
• Capalbo S, Battista C, Delia M, Ciancio A, De Santis G, Dargenio M, Diomede D, Liso V Evaluation of tumor necrosis factor-alpha and erythropoietin serum levels in B-cell chronic lymphocytic leukemia patients with anemia. Acta Haematol., 2002-01-01;108(2):84-9. 2002-01-01 [PMID: 12187026] (Human)
• Shalev H, H÷Û beta l ®ð, Kapleushnik Y, =Å|JuacïÐ, Haeskelzon L, Degani O, Kransnov T, Sphilberg O, Moser A, Yaniv I, Tamary H Clinical and laboratory manifestations of congenital dyserythropoietic anemia type I in young adults. ˆ9—s_àݺó<bz¸ƒÑŸþ鿵, 2002-03-01;68(3):170-4. 2002-03-01 [PMID: 12068798] (Human)
• Fitzsimons EJ, Houston T, Munro R, Sturrock RD, Speekenbrink AB, Brock JH Erythroblast iron metabolism and serum soluble transferrin receptor values in the anemia of rheumatoid arthritis. Arthritis Rheum., 2002-04-15;47(2):166-71. 2002-04-15 [PMID: 11954010] (Human)

FAQs for TfR (Transferrin R) (DTFR1). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: TFRC