Human sFRP-3 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human sFRP-3 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: FRZB

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human sFRP-3 DuoSet ELISA, 15 Plate

• FIZ
• FREOS1
• Frezzled
• Fritz
• Frizzled-related protein 1
• frizzled-related protein
• FRP
• FRP-3
• FRZB
• Frzb1
• FRZB-1
• FRZB1sFRP-3
• FRZB-PEN
• FZRB
• hFIZ
• secreted frizzled-related protein 3
• sFRP3
• sFRP-3
• SFRP3frezzled
• SRFP3frizzled homolog-related

Background

Secreted Frizzled related proteins are secreted glycoproteins with homology to the Wnt-binding domain of the Frizzled family of transmembrane receptors. sFRPs contain an N-terminal Frizzled-like cysteine-rich domain (CRD) with 10 conserved cysteines and a C-terminal heparin-binding region. sFRPs function as soluble antagonists of Wnt signaling by binding directly to Wnt proteins and preventing their interactions with Frizzled receptors.

Publications for sFRP-3/FRZB (DY192)(10)

Publications using DY192

• T Ueland, E Astrup, K Otterdal, T Lekva, J Janardhana, JAJ Prakash, K Thomas, AE Michelsen, P Aukrust, GM Varghese, JK Damås Secreted Wnt antagonists in scrub typhus PloS Neglected Tropical Diseases, 2021-04-29;15(4):e0009185. 2021-04-29 [PMID: 33914733] (Human)
• T Kwan, M Kazamel, K Thoenes, Y Si, N Jiang, PH King Wnt antagonist FRZB is a muscle biomarker of denervation atrophy in amyotrophic lateral sclerosis Sci Rep, 2020-10-07;10(1):16679. 2020-10-07 [PMID: 33028902] (Human)
• X Huang, JN Post, L Zhong, J Leijten, S Larsson, M Karperien, A Struglics Dickkopf-related protein 1 and Gremlin 1 show different response than Frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis Osteoarthr. Cartil., 2018-03-08;0(0):. 2018-03-08 [PMID: 29526783] (Human)
• EZ Hoseth, F Krull, I Dieset, RH Mørch, S Hope, ES Gardsjord, NE Steen, I Melle, HR Brattbakk, VM Steen, P Aukrust, S Djurovic, OA Andreassen, T Ueland Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder Transl Psychiatry, 2018-03-06;8(1):55. 2018-03-06 [PMID: 29507296] (Human)
• L Zhong, S Schivo, X Huang, J Leijten, M Karperien, JN Post Nitric Oxide Mediates Crosstalk between Interleukin 1? and WNT Signaling in Primary Human Chondrocytes by Reducing DKK1 and FRZB Expression Int J Mol Sci, 2017-11-22;18(11):. 2017-11-22 [PMID: 29165387] (Human)
• A Abraityte, IG Lunde, ET Askevold, AE Michelsen, G Christense, P Aukrust, A Yndestad, A Fiane, A Andreassen, S Aakhus, CP Dahl, L Gullestad, K Broch, T Ueland Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy Sci Rep, 2017-06-14;7(1):3490. 2017-06-14 [PMID: 28615692] (Human)
• Askevold E, Gullestad L, Nymo S, Kjekshus J, Yndestad A, Latini R, Cleland J, McMurray J, Aukrust P, Ueland T Secreted Frizzled Related Protein 3 in Chronic Heart Failure: Analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). PLoS ONE, 2015-08-19;10(8):e0133970. 2015-08-19 [PMID: 26288364] (Human)
• Leijten , Jeroen, Georgi , Nicole, Moreira Teixeira , Liliana, van Blitterswijk , Clemens, Post , Janine N, Karperien , Marcel Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate. Proc Natl Acad Sci U S A, 2014-09-09;111(38):13954-9. 2014-09-09 [PMID: 25205812] (Human)
• Leijten , Jeroen C, Moreira Teixeira , Liliana, Landman , Ellie B, van Blitterswijk , Clemens, Karperien , Marcel Hypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae. PLoS ONE, 2012-11-21;7(11):e49896. 2012-11-21 [PMID: 23185479] (Mouse)
• Ekstrom EJ, Sherwood V, Andersson T Methylation and loss of secreted frizzled-related protein 3 enhances melanoma cell migration and invasion. PLoS ONE, 2011-04-08;6(4):e18674. 2011-04-08 [PMID: 21494614] (Human)

FAQs for sFRP-3/FRZB (DY192). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: FRZB