Human MICB DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human MICB DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: MICB

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human MICB DuoSet ELISA, 15 Plate

• MHC class I chain-related protein B
• MHC class I mic-B antigen
• MHC class I polypeptide-related sequence B
• MICB
• MIC-B
• PERB11.2MHC class I-like molecule PERB11.2-IMX
• stress inducible class I homolog

Background

MHC class I chain-related genes MICA and MICB are transmembrane glycoproteins that function as ligands for human NKG2D. The two proteins are highly related, sharing 85% amino acid identity, but are also polymorphic. Recognition of MICA or MICB by NKG2D results in the activation of NK cell cytolytic activity and/or cytokine production. MICA/B are minimally expressed on normal cells, but are frequently expressed on or shed from epithelial tumors and can be induced by bacterial and viral infections. MICA and MICB recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.

Publications for MICB (DY1599)(21)

Publications using DY1599

• Pogoda-Weso?owska, A;?wi?tek, A;Synowiec, A;Zdanowski, R;Stachura, I;Szewczuk, A;Pietras, E;St?pie?, A; The role of selected NKG2DLs such as MICA, MICB and ULBP4 as potential markers in multiple sclerosis Scientific reports 2025-07-29 [PMID: 40730869] (Human)
• Toyoda, H;Kuramasu, A;Hosonuma, M;Murayama, M;Narikawa, Y;Isobe, J;Baba, Y;Tajima, K;Funayama, E;Shida, M;Maruyama, Y;Sasaki, A;Hirasawa, Y;Tsurui, T;Ariizumi, H;Ishiguro, T;Suzuki, R;Kobayashi, S;Horiike, A;Hida, N;Sambe, T;Nobe, K;Wada, S;Kobayashi, H;Tsuji, M;Kobayashi, S;Tsunoda, T;Kudo, Y;Kiuchi, Y;Yoshimura, K; MHC class I polypeptide-related sequence B shedding modulates pancreatic tumor immunity via the activation of NKG2DLow T cells Scientific reports 2024-10-08 [PMID: 39379424] (Human)
• S Badrinath, MO Dellacheri, A Li, S Zheng, X Zhang, M Sobral, JW Pyrdol, KL Smith, Y Lu, S Haag, H Ijaz, F Connor-Str, T Kaisho, G Dranoff, GC Yuan, DJ Mooney, KW Wucherpfen A vaccine targeting resistant tumours by dual T cell plus NK cell attack Nature, 2022-05-25;0(0):. 2022-05-25 [PMID: 35614223] (Mouse)
• D Samarkanov, S Cox, D Hernandez, L Rodriguez, ML Pérez, A Madrigal, A Vilarrodon, S Querol, RP Casaroli-M Cord blood and amniotic membrane extract eye drop preparations display immune-suppressive and regenerative properties Scientific Reports, 2021-07-02;11(1):13754. 2021-07-02 [PMID: 34215804] (Human)
• DP Muñoz, SM Yannone, A Daemen, Y Sun, F Vakar-Lope, M Kawahara, AM Freund, F Rodier, JD Wu, PY Desprez, DH Raulet, PS Nelson, LJ van 't Vee, J Campisi, JP Coppé Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging JCI Insight, 2019-06-11;5(0):. 2019-06-11 [PMID: 31184599] (Human)
• SC Formenti, NP Rudqvist, E Golden, B Cooper, E Wennerberg, C Lhuillier, C Vanpouille, K Friedman, L Ferrari de, KW Wucherpfen, A Heguy, N Imai, S Gnjatic, RO Emerson, XK Zhou, T Zhang, A Chachoua, S Demaria Radiotherapy induces responses of lung cancer to CTLA-4 blockade Nat. Med., 2018-11-05;0(0):. 2018-11-05 [PMID: 30397353] (Human)
• H Ghadially, L Brown, C Lloyd, L Lewis, A Lewis, J Dillon, R Sainson, J Jovanovic, NJ Tigue, D Bannister, L Bamber, V Valge-Arch, RW Wilkinson MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue Br. J. Cancer, 2017-03-23;0(0):. 2017-03-23 [PMID: 28334733] (Human)
• Lu S, Zhang J, Liu D, Li G, Staveley-O'Carroll K, Li Z, Wu J Nonblocking Monoclonal Antibody Targeting Soluble MIC Revamps Endogenous Innate and Adaptive Antitumor Responses and Eliminates Primary and Metastatic Tumors. Clin Cancer Res, 2015-06-23;21(21):4819-30. 2015-06-23 [PMID: 26106076] (Mouse)
• Zingoni A, Cecere F, Vulpis E, Fionda C, Molfetta R, Soriani A, Petrucci M, Ricciardi M, Fuerst D, Amendola M, Mytilineos J, Cerboni C, Paolini R, Cippitelli M, Santoni A Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells. J Immunol, 2015-06-12;195(2):736-48. 2015-06-12 [PMID: 26071561] (Human)
• Cox S, Laza-Briviesca R, Pearson H, Soria B, Gibson D, Gomez S, Madrigal J, Saudemont A Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity. Eur J Immunol, 2015-06-09;45(8):2324-34. 2015-06-09 [PMID: 25991034] (Human)
• Giannattasio A, Weil S, Kloess S, Ansari N, Stelzer E, Cerwenka A, Steinle A, Koehl U, Koch J Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids. BMC Cancer, 2015-05-03;15(0):351. 2015-05-03 [PMID: 25933805] (Human)
• Gonzalez-Foruria I, Santulli P, Chouzenoux S, Carmona F, Batteux F, Chapron C Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity. PLoS ONE, 2015-03-16;10(3):e0119961. 2015-03-16 [PMID: 25775242] (Human)
• Reiners K, Kessler J, Sauer M, Rothe A, Hansen H, Reusch U, Hucke C, Kohl U, Durkop H, Engert A, von Strandmann E Rescue of impaired NK cell activity in hodgkin lymphoma with bispecific antibodies in vitro and in patients. Mol Ther, 2013-03-05;21(4):895-903. 2013-03-05 [PMID: 23459515] (Human)
• Yamanegi K, Yamane J, Kobayashi K Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fas- and NK cell-mediated cell death. Int. J. Oncol., 2012-04-19;41(1):83-91. 2012-04-19 [PMID: 22576685] (Human)
• Morisaki T, Onishi H, Koya N Combinatorial Cytotoxicity of Gemcitabine and Cytokine-activated Killer Cells in Hepatocellular Carcinoma via the NKG2D-MICA/B System. Anticancer Res., 2011-07-01;31(7):2505-10. 2011-07-01 [PMID: 21873167] (Human)
• Nuckel H, Switala M, Sellmann L, Horn PA, Durig J, Duhrsen U, Kuppers R, Grosse-Wilde H, Rebmann V The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia. Leukemia, 2010-04-29;24(6):1152-9. 2010-04-29 [PMID: 20428196] (Human)
• Stanzer S, Janesch B, Resel M, Augustin T, Samonigg H, Bauernhofer T The role of activation-induced cell death in the higher onset of spontaneous apoptosis of NK cell subsets in patients with metastatic epithelial cancer. Cell. Immunol., 2009-11-26;261(2):99-104. 2009-11-26 [PMID: 20035932] (Human)
• Ho VT, Vanneman M, Kim H, Sasada T, Kang YJ, Pasek M, Cutler C, Koreth J, Alyea E, Sarantopoulos S, Antin JH, Ritz J, Canning C, Kutok J, Mihm MC, Dranoff G, Soiffer R Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation. Proc. Natl. Acad. Sci. U.S.A., 2009-08-26;106(37):15825-30. 2009-08-26 [PMID: 19717467] (Human)
• Wu JD, Atteridge CL, Wang X, Seya T, Plymate SR Obstructing shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation. Clin. Cancer Res., 2009-01-15;15(2):632-40. 2009-01-15 [PMID: 19147769] (Mouse)
• Cerboni C, Ardolino M, Santoni A, Zingoni A Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells. Blood, 2009-01-05;113(13):2955-64. 2009-01-05 [PMID: 19124832] (Human)
• Siemens DR, Hu N, Sheikhi AK, Chung E, Frederiksen LJ, Pross H, Graham CH Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide. Cancer Res., 2008-06-15;68(12):4746-53. 2008-06-15 [PMID: 18559521] (Human)

FAQs for MICB (DY1599). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: MICB