MICB Products

Description

MICB encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. [provided by RefSeq]

Bioinformatics

Product By Gene ID	4277
Alternate Names	MHC class I chain-related protein B MHC class I mic-B antigen MHC class I polypeptide-related sequence B MICB MIC-B PERB11.2MHC class I-like molecule PERB11.2-IMX stress inducible class I homolog

Research Areas for MICB

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Biologically Active Proteins

Related MICB Blog Posts

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Harnessing Natural Killer Cell Activity for Anti-Tumor Immunotherapy By Victoria Osinski, PhDWhat’s “Natural” About Natural Killer (NK) Cells?For immunologists, the term cytotoxicity often conjures up images of an army of antigen specific CD8+ T cells deploying to ...    Read more.

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