Human IL-28B/IFN-lambda 3 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-28B/IFN-lambda 3 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IFNL3

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-28B/IFN-lambda 3 DuoSet ELISA, 15 Plate

• interleukin-28B
• IFN-lambda 3
• IL28B
• IL-28B
• IL28C
• interferon, lambda 3

Background

Human/mouse IL-28A (IFN-lambda 2), IL-28B (IFN-lambda 3), and human IL-29 (IFN-lambda 1) are class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11 - 13% amino acid (aa) sequence identity) and type I IFN family (15 - 19% aa sequence identity). These cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor beta (IL-10 R beta) and a novel IL-28 receptor alpha (IL-28 R alpha, also known as IFN-lambda R1). Mouse IL-28 shares 61%, 62%, and 52% aa identity with human IL-28A, IL-28B, and IL-29, respectively.

Publications for IL-28B/IFN-lambda 3 (DY5259)(2)

Publications using DY5259

• A Rajamanick, NP Kumar, AN Pandiaraj, N Selvaraj, S Munisankar, RM Renji, V Venkatrama, M Murhekar, JWV Thangaraj, MS Kumar, CPG Kumar, T Bhatnagar, M Ponnaiah, R Sabarinath, V Saravanaku, S Babu Restoration of dendritic cell homeostasis and Type I/Type III interferon levels in convalescent COVID-19 individuals BMC immunology, 2022-10-26;23(1):51. 2022-10-26 [PMID: 36289478] (Human)
• Osterlund P, Strengell M, Sarin L, Poranen M, Fagerlund R, Melen K, Julkunen I Incoming influenza A virus evades early host recognition, while influenza B virus induces interferon expression directly upon entry. J Virol, 2012;86(20):11183-93. 2012 [PMID: 22855501] (Human)

Bioinformatics

• Gene Symbol: IFNL3