Human IL-13 R alpha 2 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-13 R alpha 2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL13RA2

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-13 R alpha 2 DuoSet ELISA, 15 Plate

• cancer/testis antigen 19
• CD213a2 antigen
• CD213a2
• CT19
• IL-13 R alpha 2
• IL-13 receptor subunit alpha-2
• IL13BP
• IL13R alpha 2
• IL-13R subunit alpha-2
• IL13R
• IL-13R
• IL13RA2
• IL-13Ra2
• IL-13R-alpha-2
• interleukin 13 binding protein
• interleukin 13 receptor alpha 2 chain
• interleukin 13 receptor, alpha 2
• interleukin-13 receptor subunit alpha-2
• Interleukin-13-binding protein

Background

Two members of the type 5 subfamily of type I cytokine receptors can serve as receptors for IL-13. IL-13 can bind to IL-13 R alpha 1 (CD213a1; previously designated IL-13 R alpha or NR4) with low affinity, then recruits the IL-4 R alpha chain to form a high affinity receptor, causing downstream STAT6 activation. Alternately, IL-13 can bind IL-13 R alpha 2 (CD213a2) with high affinity; this interaction does not cause activation of STAT6, but does induce TGF-beta production. IL-13 R alpha 1 and IL-13 R alpha 2 each have three extracellular fibronectin type III domains, two cytokine receptor homology modules and a WSXWS motif typical of the class I cytokine receptor family, but IL-13 R alpha 2 has a much shorter cytoplasmic tail. IL-13 R subunits can be expressed on monocytes, macrophages, fibroblasts, human B cells, basophils, eosinophils, endothelial cells, and smooth muscle cells.

Publications for IL-13R alpha 2 (DY614)(5)

Publications using DY614

• D Keresztes, A Csizmarik, N Nagy, O Módos, T Fazekas, T Bracht, B Sitek, K Witzke, M Puhr, S Sevcenco, G Kramer, S Shariat, Z Küronya, L Takács, I Tornyi, J Lázár, B Hadaschik, A Lászik, M Sz?cs, P Nyirády, T Szarvas Comparative proteome analysis identified CD44 as a possible serum marker for docetaxel resistance in castration-resistant prostate cancer Journal of Cellular and Molecular Medicine, 2021-12-30;0(0):. 2021-12-30 [PMID: 34970839] (Human)
• O'Toole M, Legault H, Ramsey R, Wynn TA, Kasaian MT A novel and sensitive ELISA reveals that the soluble form of IL-13R-alpha2 is not expressed in plasma of healthy or asthmatic subjects. Clin. Exp. Allergy, 2008-02-25;38(4):594-601. 2008-02-25 [PMID: 18307523] (Human)
• Matsumura M, Inoue H, Matsumoto T, Nakano T, Fukuyama S, Matsumoto K, Takayama K, Saito M, Kawakami K, Nakanishi Y Endogenous metalloprotease solubilizes IL-13 receptor alpha2 in airway epithelial cells. Biochem. Biophys. Res. Commun., 2007-06-19;360(2):464-9. 2007-06-19 [PMID: 17603012] (Human)
• Daines MO, Chen W, Tabata Y, Walker BA, Gibson AM, Masino JA, Warrier MR, Daines CL, Wenzel SE, Hershey GK Allergen-dependent solubilization of IL-13 receptor alpha2 reveals a novel mechanism to regulate allergy. J. Allergy Clin. Immunol., 2006-11-30;119(2):375-83. 2006-11-30 [PMID: 17140645] (Human)
• Daines MO, Tabata Y, Walker BA, Chen W, Warrier MR, Basu S, Hershey GK Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling. J. Immunol., 2006-06-15;176(12):7495-501. 2006-06-15 [PMID: 16751396] (Human)

FAQs for IL-13R alpha 2 (DY614). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: IL13RA2