Human CEACAM-1/CD66a DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human CEACAM-1/CD66a DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CEACAM1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CEACAM-1/CD66a DuoSet ELISA, 15 Plate

• antigen CD66
• BGP1
• BGP-1
• BGP1BGPBiliary glycoprotein 1
• BGPI
• Biliary Glycoprotein 1
• biliary glycoprotein adhesion molecule
• carcinoembryonic antigen-related cell adhesion molecule 1 (biliaryglycoprotein)
• carcinoembryonic antigen-related cell adhesion molecule 1
• CD66a antigen
• CD66a
• Cea-1
• CEACAM1
• CEACAM-1
• Hv-1
• Hv-2
• MHVR

Background

CEACAM-1, also known as CD66a, is an immunoglobulin superfamily protein that is expressed on neutrophils, activated NK cells, bile duct and colonic epithelial cells, and endothelial cells. CEACAM-1 is heavily glycosylated and carries high mannose residues and (sialyl) Lewis-x. It is expressed as at least three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. It engages in homotypic adhesion and heterotypic adhesion with CEACAM-3/CD66d and CEACAM-6/CD66c. On neutrophils, CEACAM-1 additionally binds to dendritic cell DC-SIGN via its Lewis-x moiety, inducing dendritic cell maturation and a subsequent Th1-type response.

Publications for CEACAM1/CD66a (DY2244)(6)

Publications using DY2244

• AH Ren, I Prassas, A Soosaipill, S Jarvi, S Gallinger, V Kulasingam, EP Diamandis Investigating a novel multiplex proteomics technology for detection of changes in serum protein concentrations that may correlate to tumor burden F1000Research, 2020-07-20;9(0):732. 2020-07-20 [PMID: 33274048] (Human)
• K Lashkari, GC Teague, U Beattie, J Betts, S Kumar, MM McLaughlin, FJ López Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration PLoS ONE, 2020-08-07;15(8):e0236283. 2020-08-07 [PMID: 32764794] (Human)
• Y Wu, Z Yang, L Zhu, Q Su, L Qin Association of circulating CEACAM1 levels and insulin sensitivity in gestational diabetes mellitus BMC Endocr Disord, 2020-05-15;20(1):66. 2020-05-15 [PMID: 32414367] (Human)
• J Song, SL Merbs, LJ Sokoll, DW Chan, Z Zhang A multiplex immunoassay of serum biomarkers for the detection of uveal melanoma Clin Proteomics, 2019-03-05;16(0):10. 2019-03-05 [PMID: 30867659]
• O'Brien D, Sandanayake N, Jenkinson C, Gentry-Maharaj A, Apostolidou S, Fourkala E, Camuzeaux S, Blyuss O, Gunu R, Dawnay A, Zaikin A, Smith R, Jacobs I, Menon U, Costello E, Pereira S, Timms J Serum CA19-9 is significantly upregulated up to 2 years before diagnosis with pancreatic cancer: implications for early disease detection. Clin Cancer Res, 2014-06-17;21(3):622-31. 2014-06-17 [PMID: 24938522] (Human)
• Kluger HM, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, Sznol M, Ariyan S, Molinaro A, Halaban R Plasma markers for identifying patients with metastatic melanoma. Clin. Cancer Res., 2011-04-12;17(8):2417-25. 2011-04-12 [PMID: 21487066] (Human)

Bioinformatics

• Gene Symbol: CEACAM1