HLA DRB1 Antibody (SPM289) [DyLight 488]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P
Clone
SPM289
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

HLA DRB1 Antibody (SPM289) [DyLight 488] Summary

Immunogen
Activated human peripheral blood mononuclear cells
Localization
Cell surface
Specificity
This MAb reacts with the beta-chain of HLA-DR antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the SPM289 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts.
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for HLA DRB1 Antibody (SPM289) [DyLight 488]

  • Clone P2-beta-3
  • DR1
  • DR-1
  • DR12
  • DR-12
  • DR13
  • DR-13
  • DR14
  • DR-14
  • DR16
  • DR-16
  • DR4
  • DR-4
  • DR5
  • DR-5
  • DR7
  • DR-7
  • DR8
  • DR-8
  • DR9
  • DR-9
  • DRB1
  • DRw10
  • DRw11
  • DRw8
  • DW2.2/DR2.2
  • FLJ75017
  • FLJ76359
  • HLA class II antigen beta chain
  • HLA class II histocompatibility antigen, DR-1 beta chain
  • HLA-DR1B
  • HLA-DRB
  • HLA-DRB1*
  • HLA-DRB2
  • HLA-DR-beta 1
  • human leucocyte antigen DRB1
  • leucocyte antigen DR beta 1 chain
  • leucocyte antigen DRB1
  • lymphocyte antigen DRB1
  • major histocompatibility complex, class II, DR beta 1
  • MHC class II antigen DRB1*1
  • MHC class II antigen DRB1*10
  • MHC class II antigen DRB1*11
  • MHC class II antigen DRB1*12
  • MHC class II antigen DRB1*13
  • MHC class II antigen DRB1*14
  • MHC class II antigen DRB1*15
  • MHC class II antigen DRB1*16
  • MHC class II antigen DRB1*3
  • MHC class II antigen DRB1*4
  • MHC class II antigen DRB1*7
  • MHC class II antigen DRB1*8
  • MHC class II antigen DRB1*9
  • MHC class II antigen HLA-DR13
  • MHC class II HLA-DR beta 1 chain
  • MHC class II HLA-DR-beta cell surface glycoprotein
  • MHC class II HLA-DRw10-beta
  • SS1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for HLA-DR Antibody (NBP2-34756G). (Showing 1 - 1 of 1 FAQ).

  1. We are interested in custom labeling our antibodies to be able to integrate new markers into already existing multicolor FACS panels. We would be glad to receive pricing and general order information for anti-HLA-DRB1 and anti-HLA-DRB5. To estimate expenses for future antibody labeling orders it would be helpful to know on what basis (amount, type, etc.) the price is going to be calculated. Right now the antibodies are still in mouse ascites. Would it be possible to integrate the elution of the antibodies from the ascites before labeling as part of the service agreement?
    • While we do not generally do this kind of custom purification unless it is for very large amounts of antibody, we do have a number of kits available that may be of use to you. Since an antibody that is still in ascites can not be labeled, it will need to be purified. A list of our kits available for this can be found at the following link: AbSelect. Once the antibodies are purified, they can be labeled with any number of different colors. A list of these kits for labeling can be found at the following link: Lightning-Link.

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