Species: Hu, Pm, Mu(-)
Applications: WB, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Pm
Applications: WB, Flow, ICC/IF, IHC, CyTOF-ready, ICC/IF
Host: Mouse Monoclonal
Species: Hu, Pm
Applications: WB, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: PAGE
Description
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
3123 |
| Alternate Names |
- Clone P2-beta-3
- DR1
- DR-1
- DR12
- DR-12
- DR13
- DR-13
- DR14
- DR-14
- DR16
- DR-16
- DR4
- DR-4
- DR5
- DR-5
- DR7
- DR-7
- DR8
- DR-8
- DR9
- DR-9
- DRB1
- DRw10
- DRw11
- DRw8
- DW2.2/DR2.2
- FLJ75017
- FLJ76359
- HLA class II antigen beta chain
- HLA class II histocompatibility antigen, DR-1 beta chain
- HLA-DR1B
- HLA-DRB
- HLA-DRB1*
- HLA-DRB2
- HLA-DR-beta 1
- human leucocyte antigen DRB1
- leucocyte antigen DR beta 1 chain
- leucocyte antigen DRB1
- lymphocyte antigen DRB1
- major histocompatibility complex, class II, DR beta 1
- MHC class II antigen DRB1*1
- MHC class II antigen DRB1*10
- MHC class II antigen DRB1*11
- MHC class II antigen DRB1*12
- MHC class II antigen DRB1*13
- MHC class II antigen DRB1*14
- MHC class II antigen DRB1*15
- MHC class II antigen DRB1*16
- MHC class II antigen DRB1*3
- MHC class II antigen DRB1*4
- MHC class II antigen DRB1*7
- MHC class II antigen DRB1*8
- MHC class II antigen DRB1*9
- MHC class II antigen HLA-DR13
- MHC class II HLA-DR beta 1 chain
- MHC class II HLA-DR-beta cell surface glycoprotein
- MHC class II HLA-DRw10-beta
- SS1
|
Research Areas for HLA DRB1
Find related products by research area and learn more about each of the different research areas below.
AsthmaImmunology
