Histone H2AX Antibody (1077751) [Alexa Fluor® 405]

• Reactivity: Hu
• Applications: IHC
• Clone: 1077751
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

Histone H2AX Antibody (1077751) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human H2AX
  Gly3-Ser131
  Accession # P16104
• Specificity: Detects human Histone H2AX.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: H2AX
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Histone H2AX Antibody (1077751) [Alexa Fluor® 405]

• H2A.X
• H2A/X
• H2AFX
• Histone H2AX

Background

Histone H2AX is a core histone protein that is phosphorylated at S139 in cells exposed to DNA double-strand break-inducing agents, such as ionizing radiation. The S139 phosphorylated H2AX, termed gamma -H2AX, marks the site of DNA double-strand breaks and serves to recruit cell cycle checkpoint and DNA repair factors to the site of damage.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: H2AX