Histamine N-Methyltransferase/HNMT Antibody [Allophycocyanin]

• Reactivity: Hu
• Applications: WB, ELISA, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Allophycocyanin

Histamine N-Methyltransferase/HNMT Antibody [Allophycocyanin] Summary

• Immunogen: Produced in rabbits immunized with purified, recombinant Human Histamine N-Methyltransferase/HNMT (Accession#: AAH20677.1; Met 1-Ala 292)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HNMT
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Antigen and protein A Affinity-purified

Alternate Names for Histamine N-Methyltransferase/HNMT Antibody [Allophycocyanin]

• EC 2.1.1.8
• Histamine NMethyltransferase
• Histamine N-Methyltransferase
• HMT
• HNMT
• HNMT-S1
• HNMT-S2

Background

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HNMT