Histamine H3R Antibody

Product Discontinued

Histamine H3R Antibody Summary

• Immunogen: Peptide with sequence C-ERPRSLKRGSKP corresponding to internal region according to NP_009163.2.
• Epitope: internal region
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: HRH3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000
• Application Notes: WB: Preliminary experiments in human brain (hippocampus) and in rat brain lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for Histamine H3R Antibody

• GPCR97
• GPCR97G protein-coupled receptor 97
• G-protein coupled receptor 97
• H3R
• HH3R
• Histamine H3 R
• histamine H3 receptor
• Histamine H3R
• histamine receptor H3
• HRH3

Background

H3 Histamine Receptor regulates the release of the neurotransmitters norepinephrine and somatostatin. In histamine-containing neurons of the brain, the H3 receptor acts as a presynaptic autoreceptor, while in nonhistamine-containing neurons in both the central and peripheral nervous systems, it acts as a presynaptic heteroreceptor. Multiple isoforms of H3 receptors are produced by alternative splicing. Histamine H3 receptor has been reported primarily in brain. ESTs have been isolated from brain (normal and cancer), breast cancer, colon cancer, and retinoblastoma libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Histamine H3R Antibody (NBP1-47204)(1)

Publication using NBP1-47204

• Cricco GP, Mohamad NA, Sambuco LA et al. Histamine regulates pancreatic carcinoma cell growth through H3 and H4 receptors. Inflamm Res 2008-01-01 [PMID: 18345506]

Bioinformatics

• Gene Symbol: HRH3
• Entrez:
  • 11255(Human)
  • 99296(Mouse)
  • 85268(Rat)
• Uniprot:
  • NP_009163.2(Human)