GUCY2C Antibody [ADC] - (Indusatumab Vedotin, Research Grade)

Immobilized Human Guanylyl Cyclase C/GUCY2C, His Tag at 2 ug/mL can bind Guanylyl Cyclase C/Guanylyl Cyclase C/GUCY2C, EC50 is 0.01160 ug/mL.

Human Guanylyl Cyclase C/GUCY2C CHO Cell Line were stained with Guanylyl Cyclase C/Guanylyl Cyclase C/GUCY2C and negative control protein respectively, washed and then followed by PE and analyzed with FACS,The EC50 is 0.05 mug/mL.

• Reactivity: Hu
• Applications: ELISA, Flow, Func
• Clonality: Monoclonal
• Host: Human
• Conjugate: ADC
• Concentration: LYOPH

GUCY2C Antibody [ADC] - (Indusatumab Vedotin, Research Grade) Summary

• Description: This product is an Antibody-Drug Conjugate (ADC) for Research Use Only (RUO).
  
  Indusatumab vedotin is an antibody-drug conjugate that is under development for the treatment of pancreatic cancer and other gastrointestinal cancers. It consists of a monoclonal antibody (indusatumab) that targets the enzyme guanylate cyclase 2C which is present in some cancers, linked to an average of three to four molecules of the chemotherapeutic agent monomethyl auristatin E (MMAE).
  
  This product is shipped at ambient temperature. Upon receipt, store immediately at -20C or lower for 12 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.
• Immunogen: Guanylyl Cyclase C/GUCY2C (Uniprot: P25092)
• Source: CHO
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Purity: > 90% by SDS-PAGE and HPLC

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry
  • Functional
• Theoretical MW: 150.45 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C in powder form. Store at -80C once reconstituted.
• Buffer: Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: > 90% by SDS-PAGE and HPLC
• Reconstitution Instructions: Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Alternate Names for GUCY2C Antibody [ADC] - (Indusatumab Vedotin, Research Grade)

• DIAR6
• EC 4.6.1
• GCC
• GC-C
• guanylate cyclase 2C (heat stable enterotoxin receptor)
• Guanylate Cyclase C
• Guanylyl Cyclase C
• GUC2C
• GUC2CEC 4.6.1.2
• GUCY2C
• heat-stable enterotoxin receptor
• hSTAR
• Intestinal guanylate cyclase
• MUCIL
• STA Receptor
• StAR
• STARSTA receptor

Background

Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.