GSK-3 alpha Antibody (SBGSK3a1) - Azide and BSA Free

Western Blot: GSK-3 alpha Antibody (SBGSK3a1) [NBP1-28578] - Total cell lysates from Jurkat cells were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3alpha-UNLB. Proteins were visualized using Goat Anti-Mouse IgG, Human ads-HRP secondary antibody and chemiluminescent detection.

Product Discontinued

GSK-3 alpha Antibody (SBGSK3a1) - Azide and BSA Free Summary

• Immunogen: The immunogen is a peptide made to the amino acid region GSK3 alpha
• Specificity: Human, mouse and rat GSK-3 alpha
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: GSK3A
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:5000-10000

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: 0.1M BBS (pH 8.2)
• Preservative: No Preservative
• Concentration: 0.5 mg/ml
• Purity: Protein A or G purified

Alternate Names for GSK-3 alpha Antibody (SBGSK3a1) - Azide and BSA Free

• DKFZp686D0638
• EC 2.7.11
• EC 2.7.11.26
• glycogen synthase kinase 3 alpha
• glycogen synthase kinase-3 alpha
• GSK3 alpha
• GSK-3 alpha
• GSK3A

Background

Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3 alpha and GSK-3 beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics and cell motility.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GSK3A