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Glycogen synthases kinase 3 alpha (GSK3-alpha) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-alpha activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-alpha by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-alpha activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4).
![Western Blot GSK-3 alpha [p Ser21] Antibody](http://images.novusbio.com/fullsize2/GSK-3_alpha_AF4125_Western_Blot_5401.jpg)
![Immunohistochemistry GSK-3 alpha [p Ser21] Antibody](http://images.novusbio.com/fullsize2/GSK-3_alpha_AF4125_Immunohistochemistry_6825.jpg)
