GSK-3 alpha Antibody (288901) [Alexa Fluor® 532]

• Applications: ICC/IF
• Clone: 288901
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

GSK-3 alpha Antibody (288901) [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human GSK-3α
  Gly90-Ser483
  Accession # P49840.2
• Specificity: Detects human GSK-3 alpha . In direct ELISAs, this antibody does not detect recombinant human GSK-3 beta .
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Glycogen Synthase Kinase-3 (GSK-3) is a serine/threonine kinase initially identified as an inhibitor of glycogen synthase. Two isoforms (GSK-3 alpha and GSK-3 beta ) share 85% amino acid identity. GSK-3 alpha is inhibited by phosphorylation at S21 by Akt and other kinases. Deregulated GSK-3 has been implicated in several diseases including type II diabetes, Alzheimer’s disease, bipolar disorder, and cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.