GSK-3 alpha Antibody (288901) [DyLight 405]

• Reactivity: Hu
• Applications: ICC/IF
• Clone: 288901
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 405

GSK-3 alpha Antibody (288901) [DyLight 405] Summary

• Immunogen: E. coli-derived recombinant human GSK-3 alpha
  Gly90-Ser483
  Accession # P49840.2
• Specificity: Detects human GSK-3 alpha . In direct ELISAs, this antibody does not detect recombinant human GSK-3 beta .
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: GSK3A
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for GSK-3 alpha Antibody (288901) [DyLight 405]

• DKFZp686D0638
• EC 2.7.11
• EC 2.7.11.26
• glycogen synthase kinase 3 alpha
• glycogen synthase kinase-3 alpha
• GSK3 alpha
• GSK-3 alpha
• GSK3A

Background

Glycogen synthases kinase 3 alpha (GSK3-alpha) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-alpha activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-alpha by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-alpha activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GSK3A